Literature DB >> 14980683

Side-chain length is important for shogaols in protecting neuronal cells from beta-amyloid insult.

Darrick S H L Kim1, Jin Yung Kim.   

Abstract

Ten shogaols were synthesized to evaluate the importance of the side-chain length in protecting cells from betaA(1-42) insult using PC12 rat pheochromocytoma and IMR-32 human neuroblastoma cells. The compounds cell protectivity against betaA insult was demonstrated using 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) reduction assay. The efficacy of cell protection from betaA insult by these shogaols was shown to improve as the length of the side chain increase.

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Year:  2004        PMID： 14980683     DOI： 10.1016/j.bmcl.2003.12.041

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  8 in total

1.  6-Shogaol, an active constituent of ginger, inhibits breast cancer cell invasion by reducing matrix metalloproteinase-9 expression via blockade of nuclear factor-κB activation.

Authors:  H Ling; H Yang; S-H Tan; W-K Chui; E-H Chew
Journal:  Br J Pharmacol       Date:  2010-12       Impact factor: 8.739

2.  [6]-shogaol inhibits growth and induces apoptosis of non-small cell lung cancer cells by directly regulating Akt1/2.

Authors:  Myoung Ok Kim; Mee-Hyun Lee; Naomi Oi; Sung-Hyun Kim; Ki Beom Bae; Zunnan Huang; Dong Joon Kim; Kanamata Reddy; Sung-Young Lee; Si Jun Park; Jae Young Kim; Hua Xie; Joydeb Kumar Kundu; Zae Young Ryoo; Ann M Bode; Young-Joon Surh; Zigang Dong
Journal:  Carcinogenesis       Date:  2013-11-26       Impact factor: 4.944

3.  Identification and characterization of [6]-shogaol from ginger as inhibitor of vascular smooth muscle cell proliferation.

Authors:  Rongxia Liu; Elke H Heiss; Nadine Sider; Andreas Schinkovitz; Barbara Gröblacher; Dean Guo; Franz Bucar; Rudolf Bauer; Verena M Dirsch; Atanas G Atanasov
Journal:  Mol Nutr Food Res       Date:  2015-03-16       Impact factor: 5.914

4.  Neuroprotective effect of 6-paradol in focal cerebral ischemia involves the attenuation of neuroinflammatory responses in activated microglia.

Authors:  Bhakta Prasad Gaire; Oh Wook Kwon; Sung Hyuk Park; Kwang-Hoon Chun; Sun Yeou Kim; Dong Yun Shin; Ji Woong Choi
Journal:  PLoS One       Date:  2015-03-19       Impact factor: 3.240

5.  6-shogaol, a neuroactive compound of ginger (jahe gajah) induced neuritogenic activity via NGF responsive pathways in PC-12 cells.

Authors:  Syntyche Ling Sing Seow; Sok Lai Hong; Guan Serm Lee; Sri Nurestri Abd Malek; Vikineswary Sabaratnam
Journal:  BMC Complement Altern Med       Date:  2017-06-24       Impact factor: 3.659

Review 6.  Zingiber officinale var. rubrum: Red Ginger's Medicinal Uses.

Authors:  Shiming Zhang; Xuefang Kou; Hui Zhao; Kit-Kay Mak; Madhu Katyayani Balijepalli; Mallikarjuna Rao Pichika
Journal:  Molecules       Date:  2022-01-25       Impact factor: 4.411

7.  Optimization protocol for the extraction of 6-gingerol and 6-shogaol from Zingiber officinale var. rubrum Theilade and improving antioxidant and anticancer activity using response surface methodology.

Authors:  Ali Ghasemzadeh; Hawa Z E Jaafar; Asmah Rahmat
Journal:  BMC Complement Altern Med       Date:  2015-07-30       Impact factor: 3.659

8.  Synthesis of analogues of gingerol and shogaol, the active pungent principles from the rhizomes of Zingiber officinale and evaluation of their anti-platelet aggregation effects.

Authors:  Hung-Cheng Shih; Ching-Yuh Chern; Ping-Chung Kuo; You-Cheng Wu; Yu-Yi Chan; Yu-Ren Liao; Che-Ming Teng; Tian-Shung Wu
Journal:  Int J Mol Sci       Date:  2014-03-04       Impact factor: 5.923
  8 in total

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