| Literature DB >> 14980675 |
Xiangshu Fei1, Qi-Huang Zheng, Ji-Quan Wang, K Lee Stone, Tanya D Martinez, Kathy D Miller, George W Sledge, Gary D Hutchins.
Abstract
Radiolabeled antimitotic agents [11C]T138067 and [18F]T138067 have been synthesized for evaluation as new potential positron emission tomography (PET) biomarkers for cancer imaging. In vivo biodistribution and micro-PET imaging of [11C]T138067 were performed in breast cancer animal models MCF-7 transfected with IL-1alpha implanted athymic mice and MDA-MB-435 implanted athymic mice. The results suggest that the uptakes of [11C]T138067 in both MCF-7 transfected with IL-1alpha tumor and MDA-MB-435 tumor are non-specific binding.Entities:
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Year: 2004 PMID： 14980675 DOI： 10.1016/j.bmcl.2003.12.061
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823