Literature DB >> 14980672

Synthesis and in vitro evaluation of 7-dialkylaminomethylbenzo[g]quinoxaline-5,10-diones.

Heesoon Lee1, Sungmoon Cho, Kwon Namgoong, Jae-Kyung Jung, Jungsook Cho, Sung-Il Yang.   

Abstract

A series of benzo[g]quinoxaline-5,10-dione derivatives carrying a 7-dialkylaminomethyl substituent was synthesized and their in vitro cytotoxic activities were evaluated against four human cancer cell lines (HCT-15, SK-OV-3, MD-MB-468 and T-47D). The most active compound 9d showed cytotoxic activity comparable to that of doxorubicin against HCT-15 cancer cell line.

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Year:  2004        PMID: 14980672     DOI: 10.1016/j.bmcl.2003.12.046

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN: 0960-894X            Impact factor:   2.823


  2 in total

1.  Design, Synthesis and Cytotoxic Evaluation of Novel Chalcone Derivatives Bearing Triazolo[4,3-a]-quinoxaline Moieties as Potent Anticancer Agents with Dual EGFR Kinase and Tubulin Polymerization Inhibitory Effects.

Authors:  Mohamed Alswah; Ashraf H Bayoumi; Kamal Elgamal; Ahmed Elmorsy; Saleh Ihmaid; Hany E A Ahmed
Journal:  Molecules       Date:  2017-12-27       Impact factor: 4.411

2.  Structures and electron affinity energies of polycyclic quinones.

Authors:  Xucheng Wang; Yao Cheng; Yaofeng Yuan; Yongfan Zhang; Wenfeng Wang
Journal:  Heliyon       Date:  2022-08-05
  2 in total

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