| Literature DB >> 14980665 |
Denis Riendeau1, Myriam Salem, Angela Styhler, Marc Ouellet, Joseph A Mancini, Chun Sing Li.
Abstract
Loxoprofen, its trans-alcohol and cis-alcohol metabolites were evaluated for selectivity of inhibition of COX-2 over COX-1. The (2S,1'R,2'S)-trans-alcohol derivative was found to be the most active metabolite and to be a potent and nonselective inhibitor of COX-2 and COX-1 in both enzyme and human whole blood assays.Entities:
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Year: 2004 PMID： 14980665 DOI： 10.1016/j.bmcl.2003.12.047
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823