Literature DB >> 14980663

Novel quinazoline-quinoline alkaloids with cytotoxic and DNA topoisomerase II inhibitory activities.

Zhongze Ma1, Yoshio Hano, Taro Nomura, Yingjie Chen.   

Abstract

Two new synthetic analogues of luotonins A and F, 7-acetylaminoluotonin A (6) and 3-[3H(quinazolino-4-one)]quinoline (7) were synthesized. The new analogues, along with four natural quinazoline-quinoline alkaloids, luotonins A (1), B (2), E (3), F (4) and a synthetic deoxoluotonin F (5), showed cytotoxic activity (IC(50) 1.8-40.0 microg/mL) and DNA topoisomerase II inhibition at a concentration of 25 microM.

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Year:  2004        PMID： 14980663     DOI： 10.1016/j.bmcl.2003.12.048

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  6 in total

1.  3-(4-Chloro-phen-yl)-1-(4-nitro-phen-yl)benzo[f]quinoline.

Authors:  Shu-Liang Wang; Qing Li; Xiang-Shan Wang; Shu-Jiang Tu
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2009-08-12

2.  Design and synthesis of C-aryl angular luotonins via a one-pot aza-Nazarov-Friedlander sequence and their Topo-I inhibition studies along with C-aryl vasicinones and luotonins.

Authors:  Sivappa Rasapalli; Vamshikrishna Reddy Sammeta; Zachary F Murphy; James A Golen; Keli Agama; Yves Pommier; Sergey N Savinov
Journal:  Bioorg Med Chem Lett       Date:  2021-03-30       Impact factor: 2.940

3.  D-Ring-Modified Analogues of Luotonin A with Reduced Planarity: Design, Synthesis, and Evaluation of Their Topoisomerase Inhibition-Associated Cytotoxicity.

Authors:  Abdulrahman I Almansour; Raju Suresh Kumar; Natarajan Arumugam; Giulia Bianchini; J Carlos Menéndez; Faruq Mohammad; Kotresha Dupadahalli; Mohammad Altaf
Journal:  Biomed Res Int       Date:  2019-11-13       Impact factor: 3.411

4.  Synthesis of Novel Thiazole Derivatives Bearing β-Amino Acid and Aromatic Moieties as Promising Scaffolds for the Development of New Antibacterial and Antifungal Candidates Targeting Multidrug-Resistant Pathogens.

Authors:  Dovilė Malūkaitė; Birutė Grybaitė; Rita Vaickelionienė; Giedrius Vaickelionis; Birutė Sapijanskaitė-Banevič; Povilas Kavaliauskas; Vytautas Mickevičius
Journal:  Molecules       Date:  2021-12-23       Impact factor: 4.411

Review 5.  Multiple Molecular Mechanisms to Overcome Multidrug Resistance in Cancer by Natural Secondary Metabolites.

Authors:  Mahmoud Zaki El-Readi; Ahmed M Al-Abd; Mohammad A Althubiti; Riyad A Almaimani; Hiba Saeed Al-Amoodi; Mohamed Lotfy Ashour; Michael Wink; Safaa Yehia Eid
Journal:  Front Pharmacol       Date:  2021-05-21       Impact factor: 5.810

6.  Penicamide A, A Unique N,N'-Ketal Quinazolinone Alkaloid from Ascidian-Derived Fungus Penicillium sp. 4829.

Authors:  Senhua Chen; Minghua Jiang; Bin Chen; Jintana Salaenoi; Shah-Iram Niaz; Jianguo He; Lan Liu
Journal:  Mar Drugs       Date:  2019-09-05       Impact factor: 5.118
  6 in total

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