| Literature DB >> 14980661 |
Hitoshi Kurata1, Sayaka Suzuki, Yasuo Ohhata, Takuya Ikeda, Toru Hasegawa, Ken Kitayama, Toshimori Inaba, Keita Kono, Takafumi Kohama.
Abstract
A series of 4-oxo-1-phenyl-1,4-dihydroquinolines possessing a linker and an ammonio moiety were synthesized and found to inhibit the apical sodium-dependent bile acid transporter (ASBT). The potency of ASBT inhibition varied with the position and length of the linking tether. Compound 21e effectively lowered the total serum cholesterol levels in hamsters.Entities:
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Year: 2004 PMID： 14980661 DOI： 10.1016/j.bmcl.2003.12.063
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823