Literature DB >> 14980641

Antihyperglycemic activity of 2-methyl-3,4,5-triaryl-1H-pyrroles in SLM and STZ models.

Atul Goel1, Nidhi Agarwal, Fateh V Singh, Ashoke Sharon, Priti Tiwari, Manish Dixit, Ramendra Pratap, Arvind K Srivastava, Prakas R Maulik, Vishnu J Ram.   

Abstract

Various 3,4,5-triarylpyrroles were synthesized and evaluated for their in vivo antihyperglycemic activity in sucrose-loaded (SLM) and/or streptozotocin-induced (STZ) diabetic rat models. Three of the test compounds, 2-methyl-4,5-diphenyl-3-substituted-phenyl-1H-pyrroles (3c, d and h) showed significant inhibition on postprandial hyperglycemia in normal rats post sucrose loaded. These compounds also showed lowering of plasma glucose level in STZ-induced diabetic rat model.

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Year:  2004        PMID： 14980641     DOI： 10.1016/j.bmcl.2004.01.009

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  14 in total

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2.  Biosynthesis of Cu/KF/Clinoptilolite@MWCNTs nanocomposite and its application as a recyclable nanocatalyst for the synthesis of new Schiff base of benzoxazine derivatives and reduction of organic pollutants.

Authors:  Naghmeh Faal Hamedani; Fariba Zamani Hargalani; Faramarz Rostami-Charati
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Review 3.  Recent development in the synthesis of heterocycles by 2-naphthol-based multicomponent reactions.

Authors:  Ankita Chaudhary
Journal:  Mol Divers       Date:  2020-03-23       Impact factor: 2.943

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Journal:  Daru       Date:  2020-01-06       Impact factor: 3.117

5.  Solvent-free synthesis of new spiropyrroloindole compounds using Fe3O4/TiO2/MWCNTs MNCs via multicomponent reactions: assessment of new spiropyrroloindole antioxidant activity.

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Journal:  Mol Divers       Date:  2022-01-31       Impact factor: 3.364

6.  Effect of combination treatment of S-amlodipine with peroxisome proliferator-activated receptor agonists on metabolic and cardiovascular parameters in Zucker fa/fa rats.

Authors:  Bhagat Singh; Ganesh V Sangle; Jeya Murugan; Rinku Umrani; Subhasis Roy; Onkar Kulkarni; Arvind Semwal; Mk Unnikrishnan; Mukul Jain
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7.  Synthesis and evaluation of novel spiro derivatives for pyrrolopyrimidines as anti-hyperglycemia promising compounds.

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Journal:  J Enzyme Inhib Med Chem       Date:  2018-12       Impact factor: 5.051

Review 8.  Nitroketene N,S-acetals: synergistic building blocks for the synthesis of heterocycles.

Authors:  Sarfaraz Khan; Habibur Rahman; Md Musawwer Khan
Journal:  RSC Adv       Date:  2019-05-09       Impact factor: 4.036

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Authors:  Tayyebeh Kohestani; S Zahra Sayyed-Alangi; Zinatossadat Hossaini; Mohammad T Baei
Journal:  Mol Divers       Date:  2021-07-24       Impact factor: 2.943

10.  Synthesis and evaluation of novel pyrroles and pyrrolopyrimidines as anti-hyperglycemic agents.

Authors:  M S Mohamed; S A Ali; D H A Abdelaziz; Samar S Fathallah
Journal:  Biomed Res Int       Date:  2014-06-26       Impact factor: 3.411
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