| Literature DB >> 14980627 |
Magnus O Polla1, Louise Tottie, Carita Nordén, Marcel Linschoten, Djordje Müsil, Susanne Trumpp-Kallmeyer, Inger R Aukrust, Rune Ringom, Kjetil H Holm, Siren M Neset, Marcel Sandberg, John Thurmond, Peng Yu, Georgeta Hategan, Herb Anderson.
Abstract
A series of 3-mercapto-propionic acid derivatives that function as reversible inhibitors of carboxypeptidase U have been prepared. We present a successful design strategy using cyclic, low basicity guanidine mimetics resulting in potent, selective and bioavailable inhibitors of carboxypeptidase U (TAFIa).Entities:
Mesh：
Substances：
Year: 2004 PMID： 14980627 DOI： 10.1016/j.bmc.2003.12.039
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641