Literature DB >> 14980217

Tumor necrosis factor: an apoptosis JuNKie?

Eugene E Varfolomeev1, Avi Ashkenazi.   

Abstract

TNF's main function is to stimulate inflammation by turning on gene transcription through the IKK/NFkappaB and JNK/AP-1 signaling cascades. TNF also can trigger apoptosis through caspase-8, but the role and underlying mechanism of this activity are not fully understood. Here, we review recent data on the role of JNK in the regulation of TNF-dependent apoptosis and discuss what is known so far about how cells decide whether to live or die in response to TNF.

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Year:  2004        PMID： 14980217     DOI： 10.1016/s0092-8674(04)00166-7

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  160 in total

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2.  Gentianella acuta prevents acute myocardial infarction induced by isoproterenol in rats via inhibition of galectin-3/TLR4/MyD88/NF-кB inflammatory signalling.

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3.  Endogenous HMGB1 contributes to ischemia-reperfusion-induced myocardial apoptosis by potentiating the effect of TNF-α/JNK.

Authors:  Hu Xu; Yongwei Yao; Zhaoliang Su; Yunbo Yang; Raymond Kao; Claudio M Martin; Tao Rui
Journal:  Am J Physiol Heart Circ Physiol       Date:  2010-12-24       Impact factor: 4.733

4.  Non-cell-autonomous induction of tissue overgrowth by JNK/Ras cooperation in a Drosophila tumor model.

Authors:  Mirka Uhlirova; Heinrich Jasper; Dirk Bohmann
Journal:  Proc Natl Acad Sci U S A       Date:  2005-09-06       Impact factor: 11.205

Review 5.  Apoptosis of T cells and the control of inflammatory bowel disease: therapeutic implications.

Authors:  J Mudter; M F Neurath
Journal:  Gut       Date:  2006-09-06       Impact factor: 23.059

6.  Monte Carlo simulations of tBid association with the mitochondrial outer membrane.

Authors:  Valery G Veresov; Alexander I Davidovskii
Journal:  Eur Biophys J       Date:  2007-03-21       Impact factor: 1.733

7.  Interleukin-10 is produced by a specific subset of taste receptor cells and critical for maintaining structural integrity of mouse taste buds.

Authors:  Pu Feng; Jinghua Chai; Minliang Zhou; Nirvine Simon; Liquan Huang; Hong Wang
Journal:  J Neurosci       Date:  2014-02-12       Impact factor: 6.167

8.  Burns, inflammation, and intestinal injury: protective effects of an anti-inflammatory resuscitation strategy.

Authors:  Todd W Costantini; Carrie Y Peterson; Lauren Kroll; William H Loomis; James G Putnam; Paul Wolf; Brian P Eliceiri; Andrew Baird; Vishal Bansal; Raul Coimbra
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9.  Guggulsterone inhibits tumor cell proliferation, induces S-phase arrest, and promotes apoptosis through activation of c-Jun N-terminal kinase, suppression of Akt pathway, and downregulation of antiapoptotic gene products.

Authors:  Shishir Shishodia; Gautam Sethi; Kwang Seok Ahn; Bharat B Aggarwal
Journal:  Biochem Pharmacol       Date:  2007-03-30       Impact factor: 5.858

10.  Baculoviral inhibitors of apoptosis repeat containing (BIRC) proteins fine-tune TNF-induced nuclear factor κB and c-Jun N-terminal kinase signalling in mouse pancreatic beta cells.

Authors:  B M Tan; N W Zammit; A O Yam; R Slattery; S N Walters; E Malle; S T Grey
Journal:  Diabetologia       Date:  2012-12-20       Impact factor: 10.122
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