Literature DB >> 14979525

Evaporative light scattering detection of pyrrolizidine alkaloids.

Brian T Schaneberg1, Russell J Molyneux, Ikhlas A Khan.   

Abstract

A reverse-phase high-performance liquid chromatography method utilizing evaporative light scattering detection (ELSD) has been developed for the simultaneous detection of hepatotoxic pyrrolizidine alkaloids with and without chromophores, namely, riddelliine, riddelliine N-oxide, senecionine, senecionine N-oxide, seneciphylline, retrorsine, integerrimine, lasiocarpine and heliotrine. Pyrrolizidine alkaloids were detected in five plant extracts (Senecio spartioides, S. douglasii var. longilobus, S. jacobaea, S. intergerrimus var. exaltatus and Symphytum officinale). The detection of heliotrine (which does not contain a chromophore) was much improved by ELSD compared with photodiode array detection.

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Year:  2004        PMID： 14979525     DOI： 10.1002/pca.715

Source DB:  PubMed          Journal:  Phytochem Anal        ISSN： 0958-0344            Impact factor:   3.373


  6 in total

1.  Metabolism, genotoxicity, and carcinogenicity of comfrey.

Authors:  Nan Mei; Lei Guo; Peter P Fu; James C Fuscoe; Yang Luan; Tao Chen
Journal:  J Toxicol Environ Health B Crit Rev       Date:  2010-10       Impact factor: 6.393

2.  Analysis of gene expression changes in relation to toxicity and tumorigenesis in the livers of Big Blue transgenic rats fed comfrey (Symphytum officinale).

Authors:  Nan Mei; Lei Guo; Lu Zhang; Leming Shi; Yongming Andrew Sun; Chris Fung; Carrie L Moland; Stacey L Dial; James C Fuscoe; Tao Chen
Journal:  BMC Bioinformatics       Date:  2006-09-06       Impact factor: 3.169

3.  Mutagenicity of comfrey (Symphytum Officinale) in rat liver.

Authors:  N Mei; L Guo; P P Fu; R H Heflich; T Chen
Journal:  Br J Cancer       Date:  2005-03-14       Impact factor: 7.640

Review 4.  Review: DNA Barcoding and Chromatography Fingerprints for the Authentication of Botanicals in Herbal Medicinal Products.

Authors:  Bashir Mohammed Abubakar; Faezah Mohd Salleh; Mohd Shahir Shamsir Omar; Alina Wagiran
Journal:  Evid Based Complement Alternat Med       Date:  2017-04-27       Impact factor: 2.629

5.  Comparison of gene expression profiles altered by comfrey and riddelliine in rat liver.

Authors:  Lei Guo; Nan Mei; Stacey Dial; James Fuscoe; Tao Chen
Journal:  BMC Bioinformatics       Date:  2007-11-01       Impact factor: 3.169

6.  Extracting and Analyzing Pyrrolizidine Alkaloids in Medicinal Plants: A Review.

Authors:  Thomas Kopp; Mona Abdel-Tawab; Boris Mizaikoff
Journal:  Toxins (Basel)       Date:  2020-05-13       Impact factor: 4.546
  6 in total

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