Literature DB >> 14979479

Coexistent rearrangements of c-MYC, BCL2, and BCL6 genes in a diffuse large B-cell lymphoma.

Chiyoko Ueda1, Momoko Nishikori, Toshio Kitawaki, Takashi Uchiyama, Hitoshi Ohno.   

Abstract

We present a patient with stage III de novo diffuse large B-cell lymphoma. The lymphoma cells showed mature B-cell immunophenotype but lacked surface immunoglobulin (Ig) expression. Long-distance and long-distance inverse polymerase chain reaction assays to detect the oncogene/Ig gene rearrangement revealed that the cells carried 3 independent fusion genes, namely, c-MYC/Ig heavy chain gene (IgH), BCL2/IgH, and Ig lambda light chain gene/BCL6. Thus, the lymphoma cells concurrently carried t(8;14)(q24;q32), t(14;18)(q32;q21), and t(3;22)(q27;q11), which developed in association with class switching, V/D/J recombination, and somatic hypermutation, respectively. The lymphoma responded to chemoradiotherapy, and the patient has been well for 2 years, suggesting that multiple oncogene rearrangements may not necessarily be associated with poor clinical outcome.

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Year:  2004        PMID： 14979479     DOI： 10.1007/bf02983534

Source DB:  PubMed          Journal:  Int J Hematol        ISSN： 0925-5710            Impact factor:   2.490


  10 in total

1.  Molecular anatomy of BCL6 translocations revealed by long-distance polymerase chain reaction-based assays.

Authors:  H Akasaka; T Akasaka; M Kurata; C Ueda; A Shimizu; T Uchiyama; H Ohno
Journal:  Cancer Res       Date:  2000-05-01       Impact factor: 12.701

Review 2.  The role of immunoglobulin translocations in the pathogenesis of B-cell malignancies.

Authors:  T G Willis; M J Dyer
Journal:  Blood       Date:  2000-08-01       Impact factor: 22.113

Review 3.  Cellular origin of human B-cell lymphomas.

Authors:  R Küppers; U Klein; M L Hansmann; K Rajewsky
Journal:  N Engl J Med       Date:  1999-11-11       Impact factor: 91.245

4.  Small noncleaved, non-Burkitt's (Burkit-Like) lymphoma: cytogenetics predict outcome and reflect clinical presentation.

Authors:  N Macpherson; D Lesack; R Klasa; D Horsman; J M Connors; M Barnett; R D Gascoyne
Journal:  J Clin Oncol       Date:  1999-05       Impact factor: 44.544

5.  Activation of the c-myc oncogene in a precursor-B-cell blast crisis of follicular lymphoma, presenting as composite lymphoma.

Authors:  D De Jong; B M Voetdijk; G C Beverstock; G J van Ommen; R Willemze; P M Kluin
Journal:  N Engl J Med       Date:  1988-05-26       Impact factor: 91.245

6.  A 14;18 and an 8;14 chromosome translocation in a cell line derived from an acute B-cell leukemia.

Authors:  L Pegoraro; A Palumbo; J Erikson; M Falda; B Giovanazzo; B S Emanuel; G Rovera; P C Nowell; C M Croce
Journal:  Proc Natl Acad Sci U S A       Date:  1984-11       Impact factor: 11.205

7.  Refinement of the BCL2/immunoglobulin heavy chain fusion gene in t(14;18)(q32;q21) by polymerase chain reaction amplification for long targets.

Authors:  T Akasaka; H Akasaka; N Yonetani; H Ohno; H Yamabe; S Fukuhara; M Okuma
Journal:  Genes Chromosomes Cancer       Date:  1998-01       Impact factor: 5.006

8.  Rearrangement of the BCL6 gene in B-cell lymphoid neoplasms: comparison with lymphomas associated with BCL2 rearrangement.

Authors:  M Muramatsu; T Akasaka; N Kadowaki; H Ohno; H Yamabe; S Edamura; S Dor; T Mori; M Okuma; S Fukuhara
Journal:  Br J Haematol       Date:  1996-06       Impact factor: 6.998

9.  Application of long-distance polymerase chain reaction to detection of junctional sequences created by chromosomal translocation in mature B-cell neoplasms.

Authors:  T Akasaka; M Muramatsu; H Ohno; I Miura; E Tatsumi; S Fukuhara; T Mori; M Okuma
Journal:  Blood       Date:  1996-08-01       Impact factor: 22.113

10.  Frequent association of t(3;14) or variant with other lymphoma-specific translocations.

Authors:  D E Horsman; B K McNeil; M Anderson; T Shenkier; R D Gascoyne
Journal:  Br J Haematol       Date:  1995-03       Impact factor: 6.998
  10 in total
  4 in total

Review 1.  Mechanisms involved in Burkitt's tumor formation.

Authors:  M R Campanero
Journal:  Clin Transl Oncol       Date:  2008-05       Impact factor: 3.405

Review 2.  Epstein-Barr virus and Burkitt lymphoma.

Authors:  G Brady; G J MacArthur; P J Farrell
Journal:  J Clin Pathol       Date:  2007-12       Impact factor: 3.411

3.  Prognostic impact of concurrent MYC and BCL6 rearrangements and expression in de novo diffuse large B-cell lymphoma.

Authors:  Qing Ye; Zijun Y Xu-Monette; Alexandar Tzankov; Lijuan Deng; Xiaoxiao Wang; Ganiraju C Manyam; Carlo Visco; Santiago Montes-Moreno; Li Zhang; Karen Dybkær; April Chiu; Attilio Orazi; Youli Zu; Govind Bhagat; Kristy L Richards; Eric D Hsi; William W L Choi; J Han van Krieken; Jooryung Huh; Maurilio Ponzoni; Andrés J M Ferreri; Ben M Parsons; Michael B Møller; Miguel A Piris; Jane N Winter; L Jeffrey Medeiros; Shimin Hu; Ken H Young
Journal:  Oncotarget       Date:  2016-01-19

4.  PRDM15 is a key regulator of metabolism critical to sustain B-cell lymphomagenesis.

Authors:  Jia Yi Fong; David Papadopoli; Cheryl M Koh; Laura Hulea; Slim Mzoughi; Paolo Pigini; Federico Di Tullio; Giuseppe Andreacchio; Michal Marek Hoppe; Heike Wollmann; Diana Low; Matias J Caldez; Yanfen Peng; Denis Torre; Julia N Zhao; Oro Uchenunu; Gabriele Varano; Corina-Mihaela Motofeanu; Manikandan Lakshmanan; Shun Xie Teo; Cheng Mun Wun; Giovanni Perini; Soo Yong Tan; Chee Bing Ong; Muthafar Al-Haddawi; Ravisankar Rajarethinam; Susan Swee-Shan Hue; Soon Thye Lim; Choon Kiat Ong; Dachuan Huang; Siok-Bian Ng; Emily Bernstein; Dan Hasson; Keng Boon Wee; Philipp Kaldis; Anand Jeyasekharan; David Dominguez-Sola; Ivan Topisirovic; Ernesto Guccione
Journal:  Nat Commun       Date:  2020-07-14       Impact factor: 14.919
  4 in total

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