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Literature DB >> 1497902

Effect of acute inflammatory lung injury on the expression of monocyte chemoattractant protein-1 (MCP-1) in rat pulmonary alveolar macrophages.

J K Brieland¹, M L Jones, S J Clarke, J B Baker, J S Warren, J C Fantone.

Abstract

Using a well-characterized rat model of immune complex-mediated acute inflammatory lung injury, we determined that there is a time-dependent elaboration of monocyte chemotactic activity in bronchoalveolar lavage fluid. Monocyte chemotactic activity is also significantly enhanced in culture supernatants from pulmonary alveolar macrophages (PAMs) from injured rat lungs. Northern hybridization analysis revealed markedly increased expression of rat monocyte chemoattractant protein 1 (MCP-1) mRNA in PAMs obtained from rats with immune complex-induced lung injury. The increased expression of MCP-1 mRNA and associated increase in monocyte chemotactic activity present in culture supernatants of PAMs from injured rat lungs suggest that PAMs may participate in the pathogenesis of acute inflammatory lung injury by the secretion of monocyte chemoattractants including MCP-1.

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Year: 1992 PMID： 1497902 DOI： 10.1165/ajrcmb/7.2.134

Source DB: PubMed Journal: Am J Respir Cell Mol Biol ISSN： 1044-1549 Impact factor: 6.914

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Cited

15 in total

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Effect of acute inflammatory lung injury on the expression of monocyte chemoattractant protein-1 (MCP-1) in rat pulmonary alveolar macrophages.

1. MCP-1/CCR2 signalling pathway regulates hyperoxia-induced acute lung injury via nitric oxide production.

2. Inhibition of T cell recruitment and cutaneous delayed-type hypersensitivity-induced inflammation with antibodies to monocyte chemoattractant protein-1.

3. Temporal sequence of pulmonary and systemic inflammatory responses to graded polymicrobial peritonitis in mice.

4. The intratracheal administration of endotoxin: X. Dexamethasone downregulates neutrophil emigration and cytokine expression in vivo.

5. Regulatory roles of tumor necrosis factor-alpha and interleukin-1 beta in monocyte chemoattractant protein-1-mediated pulmonary granuloma formation in the rat.

6. Analysis of monocyte chemoattractant protein 1-mediated lung injury using rat lung organ cultures.

7. Interferon-gamma Stimulates Monocyte Chemotactic Protein-1 Expression by Monocytes.

8. Macrophage-derived MCPIP1 mediates silica-induced pulmonary fibrosis via autophagy.

9. Association of Heme Oxygenase 1 with Lung Protection in Malaria-Associated ALI/ARDS.

10. Chemotactic chemokines are important in the pathogenesis of irritable bowel syndrome.