Literature DB >> 14978683

Hyperhomocysteinaemia in treated patients with Huntington's disease homocysteine in HD.

Jürgen Andrich1, Carsten Saft, Anneliese Arz, Birgit Schneider, Markus W Agelink, Peter H Kraus, Wilfried Kuhn, Thomas Müller.   

Abstract

Significantly increased plasma total homocysteine levels (t-Hcys) appeared in treated Huntington disease (HD) patients compared to controls and untreated HD subjects. Because the protein Huntingtin interacts with the homocysteine metabolism modulating enzyme cystathionine beta-synthase, we hypothesize that homocysteine promotes neurodegeneration in HD.

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Year:  2004        PMID： 14978683     DOI： 10.1002/mds.10629

Source DB:  PubMed          Journal:  Mov Disord        ISSN： 0885-3185            Impact factor:   10.338


  4 in total

1.  Disruption of peripheral circadian timekeeping in a mouse model of Huntington's disease and its restoration by temporally scheduled feeding.

Authors:  Elizabeth S Maywood; Eloise Fraenkel; Catherine J McAllister; Nigel Wood; Akhilesh B Reddy; Michael H Hastings; A Jennifer Morton
Journal:  J Neurosci       Date:  2010-07-28       Impact factor: 6.167

Review 2.  Potential for therapeutic use of hydrogen sulfide in oxidative stress-induced neurodegenerative diseases.

Authors:  Rubaiya Tabassum; Na Young Jeong
Journal:  Int J Med Sci       Date:  2019-09-20       Impact factor: 3.738

3.  Integration of targeted metabolomics and transcriptomics identifies deregulation of phosphatidylcholine metabolism in Huntington's disease peripheral blood samples.

Authors:  Anastasios Mastrokolias; Rene Pool; Eleni Mina; Kristina M Hettne; Erik van Duijn; Roos C van der Mast; GertJan van Ommen; Peter A C 't Hoen; Cornelia Prehn; Jerzy Adamski; Willeke van Roon-Mom
Journal:  Metabolomics       Date:  2016-07-27       Impact factor: 4.290

4.  Gut Microbiome and Serum Metabolome Alterations Associated with Isolated Dystonia.

Authors:  Lingyan Ma; Jing Keng; Min Cheng; Hua Pan; Bo Feng; Yongfeng Hu; Tao Feng; Fan Yang
Journal:  mSphere       Date:  2021-08-04       Impact factor: 4.389
  4 in total

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