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Literature DB >> 14977992

Mycobacterial purified protein derivatives stimulate innate immunity: Malawians show enhanced tumor necrosis factor alpha, interleukin-1beta (IL-1beta), and IL-10 responses compared to those of adolescents in the United Kingdom.

Rosemary E Weir¹, Gillian F Black, Hazel M Dockrell, Sian Floyd, Paul E M Fine, Steven D Chaguluka, Sally Stenson, Elizabeth King, Bernadette Nazareth, David K Warndorff, Bagrey Ngwira, Amelia C Crampin, Lorren Mwaungulu, Lifted Sichali, Elizabeth Jarman, Linda Donovan, Jenefer M Blackwell.

Abstract

To investigate the role of innate immunity in variable efficacy of Mycobacterium bovis BCG vaccination in Malawi and the United Kingdom, we examined 24-h tumor necrosis factor alpha, interleukin-1beta (IL-1beta), and IL-10 responses to mycobacterial purified protein derivatives (PPDs). The rank order in stimulatory potency for different PPDs was the same for all three cytokines. Before vaccination Malawians made higher pro- and anti-inflammatory responses than did United Kingdom subjects. Fewer than 5% of United Kingdom subjects made IL-10 in response to any PPD, compared to 19 to 57% responders among Malawians. Priming for regulatory IL-10 may contribute to the smaller increase in gamma interferon responses in Malawians compared to United Kingdom subjects following BCG vaccination.

Entities: Disease Species

Mesh：

Substances：

Year: 2004 PMID： 14977992 PMCID： PMC356017 DOI： 10.1128/IAI.72.3.1807-1811.2004

Source DB: PubMed Journal: Infect Immun ISSN： 0019-9567 Impact factor: 3.441

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