| Literature DB >> 14977698 |
O S von Ehrenstein1, E M Maier, S K Weiland, D Carr, T Hirsch, T Nicolai, A A Roscher, E von Mutius.
Abstract
In a random sample of children (aged 9-11 years; n = 5629), who were studied according to the ISAAC phase II protocol, heterozygosity of the alpha1 antitrypsin (alpha1-AT) Pi genotypes MS or MZ, or low alpha1-AT plasma levels, were not associated with an increased risk of developing asthma. Asthmatics with low levels of alpha1-AT were particularly prone to develop airway hyperresponsiveness and reduced lung function.Entities:
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Year: 2004 PMID： 14977698 PMCID： PMC1719844 DOI： 10.1136/adc.2002.023614
Source DB: PubMed Journal: Arch Dis Child ISSN： 0003-9888 Impact factor: 3.791