BACKGROUND:Creatine supplementation has been shown to augment training-induced strength gains. The purpose of this study was to examine the effect of creatine supplementation on recovery of muscle strengthafter anterior cruciate ligament (ACL) reconstruction. HYPOTHESIS: Creatine supplementation will facilitate strength gains after ACL reconstruction. STUDY DESIGN: Double-blind, prospective, and randomized clinical trial. METHODS:Sixty patients were randomized into creatine or placebo groups. Quadriceps and hamstring strength and power were measured isokinetically. Hip flexor, abductor, and adductor strengths were measured with a handheld dynamometer prior to surgery and at 6 weeks, 12 weeks, or 6 months after surgery. RESULTS: From 6 weeks to 12 weeks after surgery, there were significant increases in strength on the involved side for knee extension (47%), knee flexion (27%), hip flexion (20%), hip abduction (9%), and hip adduction (17%). These strength improvements were unaffected by creatine supplementation with similar effects in the creatine and placebo groups. From 6 weeks to 12 weeks after surgery, there were significant increases in power on the involved side for knee extension (46%) and knee flexion (26%), but these effects were not affected by creatine supplementation. At 6 months, creatine supplementation did not affect outcome as measured by the single leg hop test for distance or the knee outcome score. CONCLUSIONS: The results demonstrate that patients do not benefit from creatine supplementation during the first 12 weeks of rehabilitation after ACL reconstruction.
RCT Entities:
BACKGROUND:Creatine supplementation has been shown to augment training-induced strength gains. The purpose of this study was to examine the effect of creatine supplementation on recovery of muscle strength after anterior cruciate ligament (ACL) reconstruction. HYPOTHESIS: Creatine supplementation will facilitate strength gains after ACL reconstruction. STUDY DESIGN: Double-blind, prospective, and randomized clinical trial. METHODS: Sixty patients were randomized into creatine or placebo groups. Quadriceps and hamstring strength and power were measured isokinetically. Hip flexor, abductor, and adductor strengths were measured with a handheld dynamometer prior to surgery and at 6 weeks, 12 weeks, or 6 months after surgery. RESULTS: From 6 weeks to 12 weeks after surgery, there were significant increases in strength on the involved side for knee extension (47%), knee flexion (27%), hip flexion (20%), hip abduction (9%), and hip adduction (17%). These strength improvements were unaffected by creatine supplementation with similar effects in the creatine and placebo groups. From 6 weeks to 12 weeks after surgery, there were significant increases in power on the involved side for knee extension (46%) and knee flexion (26%), but these effects were not affected by creatine supplementation. At 6 months, creatine supplementation did not affect outcome as measured by the single leg hop test for distance or the knee outcome score. CONCLUSIONS: The results demonstrate that patients do not benefit from creatine supplementation during the first 12 weeks of rehabilitation after ACL reconstruction.
Authors: Louis E Defrate; Kyung Wook Nha; Ramprasad Papannagari; Jeremy M Moses; Thomas J Gill; Guoan Li Journal: J Biomech Date: 2006-10-27 Impact factor: 2.712
Authors: Rick W Wright; Emily Preston; Braden C Fleming; Annunziato Amendola; Jack T Andrish; John A Bergfeld; Warren R Dunn; Chris Kaeding; John E Kuhn; Robert G Marx; Eric C McCarty; Richard C Parker; Kurt P Spindler; Michelle Wolcott; Brian R Wolf; Glenn N Williams Journal: J Knee Surg Date: 2008-07 Impact factor: 2.757
Authors: Richard B Kreider; Douglas S Kalman; Jose Antonio; Tim N Ziegenfuss; Robert Wildman; Rick Collins; Darren G Candow; Susan M Kleiner; Anthony L Almada; Hector L Lopez Journal: J Int Soc Sports Nutr Date: 2017-06-13 Impact factor: 5.150
Authors: Benjamin Wax; Chad M Kerksick; Andrew R Jagim; Jerry J Mayo; Brian C Lyons; Richard B Kreider Journal: Nutrients Date: 2021-06-02 Impact factor: 5.717
Authors: Kylie K Harmon; Jeffrey R Stout; David H Fukuda; Patrick S Pabian; Eric S Rawson; Matt S Stock Journal: Nutrients Date: 2021-05-27 Impact factor: 5.717
Authors: Thomas W Buford; Richard B Kreider; Jeffrey R Stout; Mike Greenwood; Bill Campbell; Marie Spano; Tim Ziegenfuss; Hector Lopez; Jamie Landis; Jose Antonio Journal: J Int Soc Sports Nutr Date: 2007-08-30 Impact factor: 5.150