| Literature DB >> 14977602 |
Tsunehiro Oyama1, Norio Kagawa, Naoki Kunugita, Kyoko Kitagawa, Masanori Ogawa, Tetsunosuke Yamaguchi, Rie Suzuki, Tsuyoshi Kinaga, Yasunori Yashima, Shinichi Ozaki, Toyohi Isse, Yong-Dae Kim, Heon Kim, Toshihiro Kawamoto.
Abstract
CYPs (cytochrome P450s) catalyze the conversion of numerous numbers of xenobiotics including carcinogens and drugs. CYPs can be involved in metabolic pathways of activation of procarcinogens and/or inactivation of carcinogens during the tumorigenic processes. Recently, increasing number of cancer tissues as well as normal tissues have been found to express a variety of CYPs. The local expression of CYPs in tumors appears to be very important for the management of cancers since CYPs expressed in tumors may be involved in activation and/or inactivation of anticancer drugs. The expression of CYPs in tumors may also convert endogenous substrates to metabolites that facilitate cancer development. In this review, we summarize the association of CYP expression in cancer tissues with carcinogenesis and cancer treatment.Entities:
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Year: 2004 PMID： 14977602 DOI： 10.2741/1378
Source DB: PubMed Journal: Front Biosci ISSN： 1093-4715