| Literature DB >> 14976984 |
Clarissa M Maya-Monteiro1, Liliane R Alves, Nelson Pinhal, Dulcineia S P Abdalla, Pedro L Oliveira.
Abstract
Plasma lipoproteins involved in lipid transport are target for free radical-evoked pathological conditions in several mammalian models. The main hemolymphatic protein of Boophilus microplus is a heme-binding lipoprotein (HeLp, for Heme LipoProtein) that carries dietary heme produced from degradation of vertebrate hemoglobin to tissues of the tick. Addition of heme to phospholipid liposomes resulted in intense lipid peroxidation, which was inhibited by addition of HeLp. HeLp prevented lysis of red blood cells by heme. HeLp also inhibited reactions of heme with tert-butyl hydroperoxide (t-BOOH) or hydrogen peroxide. HeLp, quite differently from other lipoproteins, presents a protective intrinsic mechanism to counteract heme toxicity, while preserving the heme molecule to be reused by the tick. This is the first report of a lipoprotein acting as an antioxidant particle against heme-induced radical damage.Entities:
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Year: 2004 PMID： 14976984 DOI： 10.1016/j.ibmb.2003.09.005
Source DB: PubMed Journal: Insect Biochem Mol Biol ISSN： 0965-1748 Impact factor: 4.714