| Literature DB >> 14975743 |
Takashi Kameda1, Kenji Ikegami, Yang Liu, Kunihiko Terada, Toshihiro Sugiyama.
Abstract
RNA interference (RNAi) has been attracting a great deal of attention. This pathway is highly conserved among most eukaryotes and believed to be important for antiviral reactions and epigenetic gene regulation. Because a temperature-sensitive RNAi was reported in both plant and insect systems, suggesting its evolutional conservation, we analyzed the effect of different temperatures on mammalian RNAi, targeting the ectopic gene expression, and detected suppression at hypothermic temperatures. This phenomenon could be critical and useful to control ectopic and internal gene expressions by RNAi.Entities:
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Year: 2004 PMID： 14975743 DOI： 10.1016/j.bbrc.2004.01.097
Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575