| Literature DB >> 14975597 |
Marcella Reale1, Carla Iarlori, Francesco Gambi, Claudio Feliciani, Anatolia Salone, Lucia Toma, Giovanna DeLuca, Mirella Salvatore, Pio Conti, Domenico Gambi.
Abstract
Elevated levels of cytokines have been detected in brains of Alzheimer's disease (AD) patients, and altered peripheral levels of IL-1beta, TNFalpha and IL-6 have been reported in these patients. We studied the ability of PBMC from patients with AD, matched with a control group, to release pro- and anti-inflammatory cytokines, and the effect of AChEI treatment on cytokine release. Our data indicates that AChEI treatment down-regulates IL-1, IL-6 and TNF, and up-regulates the expression and production of IL-4 in PBMC in AD patients, and that AChEI leads to the remodelling of the cytokine network, probably acting on the lymphocytic cholinergic system.Entities:
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Year: 2004 PMID： 14975597 DOI： 10.1016/j.jneuroim.2003.11.003
Source DB: PubMed Journal: J Neuroimmunol ISSN： 0165-5728 Impact factor: 3.478