Literature DB >> 14975589

Morphine modulates HIV-1 gp160-induced murine macrophage and human monocyte apoptosis by disparate ways.

Aditi A Kapasi1, Salvatore A Coscia, Manish P Pandya, Pravin C Singhal.   

Abstract

We studied the effect of HIV-1 gp160 protein and morphine on murine macrophage and human monocyte apoptosis. gp160 not only promoted murine macrophage apoptosis but also enhanced macrophage iNOS expression/NO generation. gp160 also altered macrophage bax and bcl-2 expression. Morphine enhanced (P<0.001) the effect of gp160 on macrophage apoptosis as well as iNOS expression/NO generation. Nevertheless, both morphine- and gp160-induced murine macrophage apoptosis was attenuated by nitric oxide synthase (NOS) inhibitors (L-NAME and L-NMMA). On the other hand, free radical scavengers such as superoxide dismutase (SOD), dimethylthiourea (DMTU) and catalase attenuated morphine and gp160-induced human monocyte apoptosis.

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Year:  2004        PMID： 14975589     DOI： 10.1016/j.jneuroim.2003.11.015

Source DB:  PubMed          Journal:  J Neuroimmunol        ISSN： 0165-5728            Impact factor:   3.478


  9 in total

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Review 6.  The role of morphine in regulation of cancer cell growth.

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7.  Morphine Promotes Tumor Angiogenesis and Increases Breast Cancer Progression.

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Review 8.  Opioids Regulate the Immune System: Focusing on Macrophages and Their Organelles.

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Review 9.  The role of morphine in animal models of human cancer: does morphine promote or inhibit the tumor growth?

Authors:  Sabrina Bimonte; Antonio Barbieri; Giuseppe Palma; Claudio Arra
Journal:  Biomed Res Int       Date:  2013-08-28       Impact factor: 3.411
  9 in total

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