| Literature DB >> 14973470 |
Timothy P Padera1, Brian R Stoll, Jessica B Tooredman, Diane Capen, Emmanuelle di Tomaso, Rakesh K Jain.
Abstract
The delivery of therapeutic drugs to solid tumours may be impaired by structural and functional abnormalities in blood and lymphatic vessels. Here we provide evidence that proliferating cancer cells cause intratumour vessels to compress and collapse. By reducing this compressive mechanical force and opening vessels, cytotoxic cancer treatments have the potential to increase blood perfusion, thereby improving drug delivery.Entities:
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Year: 2004 PMID： 14973470 DOI： 10.1038/427695a
Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962