AIM: Assess the expression of FasL, Bax, TNFa and IL-6, genes in salivary glands of primary Sjögren patients. METHODS: Twenty minor salivary glands from patients with primary Sjögren syndrome were studied by in situ hybridization with cDNA fluorescent probes. An equal number of control biopsies were included. RESULTS: Sjögren salivary glands differentially display the inflammatory cytokines and pro-apoptotic mRNAs as follows: mononuclear infiltrating cells exhibited IL-6 and TNFa, whereas the ductal epithelium and acinary cells mainly expressed FasL and Bax. Control biopsies were negative. CONCLUSION: Present data suggest that local production of inflammatory cytokines would induce the Fas and Bax pathways committing the ductal epithelium and the acinary cells to apoptosis.
AIM: Assess the expression of FasL, Bax, TNFa and IL-6, genes in salivary glands of primary Sjögren patients. METHODS: Twenty minor salivary glands from patients with primary Sjögren syndrome were studied by in situ hybridization with cDNA fluorescent probes. An equal number of control biopsies were included. RESULTS: Sjögren salivary glands differentially display the inflammatory cytokines and pro-apoptotic mRNAs as follows: mononuclear infiltrating cells exhibited IL-6 and TNFa, whereas the ductal epithelium and acinary cells mainly expressed FasL and Bax. Control biopsies were negative. CONCLUSION: Present data suggest that local production of inflammatory cytokines would induce the Fas and Bax pathways committing the ductal epithelium and the acinary cells to apoptosis.
Authors: K Yoshimoto; T Fujimoto; A Itaya-Hironaka; T Miyaoka; S Sakuramoto-Tsuchida; A Yamauchi; M Takeda; T Kasai; K Nakagawara; A Nonomura; S Takasawa Journal: Clin Exp Immunol Date: 2013-10 Impact factor: 4.330
Authors: Rafael Herrera-Esparza; Mayra Rodríguez-Rodríguez; María Elena Pérez-Pérez; Martha Adriana Badillo-Soto; Felipe Torres-Del-Muro; Juan José Bollain-Y-Goytia; Deyanira Pacheco-Tovar; Esperanza Avalos-Díaz Journal: Autoimmune Dis Date: 2013-03-05