Literature DB >> 14973120

Characterization of two methanopterin biosynthesis mutants of Methylobacterium extorquens AM1 by use of a tetrahydromethanopterin bioassay.

Madeline E Rasche1, Stephanie A Havemann, Mariana Rosenzvaig.   

Abstract

An enzymatic assay was developed to measure tetrahydromethanopterin (H(4)MPT) levels in wild-type and mutant cells of Methylobacterium extorquens AM1. H(4)MPT was detectable in wild-type cells but not in strains with a mutation of either the orf4 or the dmrA gene, suggesting a role for these two genes in H(4)MPT biosynthesis. The protein encoded by orf4 catalyzed the reaction of ribofuranosylaminobenzene 5'-phosphate synthase, the first committed step of H(4)MPT biosynthesis. These results provide the first biochemical evidence for H(4)MPT biosynthesis genes in bacteria.

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Year:  2004        PMID： 14973120      PMCID： PMC344399          DOI： 10.1128/JB.186.5.1565-1570.2004

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  30 in total

1.  Identifying two ancient enzymes in Archaea using predicted secondary structure alignment.

Authors:  H Xu; R Aurora; G D Rose; R H White
Journal:  Nat Struct Biol       Date:  1999-08

2.  Mechanism for the enzymatic formation of 4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate during the biosynthesis of methanopterin.

Authors:  M E Rasche; R H White
Journal:  Biochemistry       Date:  1998-08-11       Impact factor: 3.162

3.  C1 transfer enzymes and coenzymes linking methylotrophic bacteria and methanogenic Archaea.

Authors:  L Chistoserdova; J A Vorholt; R K Thauer; M E Lidstrom
Journal:  Science       Date:  1998-07-03       Impact factor: 47.728

4.  One-dimensional gel electrophoresis.

Authors:  D E Garfin
Journal:  Methods Enzymol       Date:  1990       Impact factor: 1.600

5.  A rapid and specific enrichment procedure for Hyphomicrobium spp.

Authors:  M M Attwood; W Harder
Journal:  Antonie Van Leeuwenhoek       Date:  1972       Impact factor: 2.271

6.  Formaldehyde activation factor, tetrahydromethanopterin, a coenzyme of methanogenesis.

Authors:  J C Escalante-Semerena; J A Leigh; K L Rinehart; R S Wolfe
Journal:  Proc Natl Acad Sci U S A       Date:  1984-04       Impact factor: 11.205

7.  Distribution of tetrahydromethanopterin-dependent enzymes in methylotrophic bacteria and phylogeny of methenyl tetrahydromethanopterin cyclohydrolases.

Authors:  J A Vorholt; L Chistoserdova; S M Stolyar; R K Thauer; M E Lidstrom
Journal:  J Bacteriol       Date:  1999-09       Impact factor: 3.490

8.  Novel methylotrophy genes of Methylobacterium extorquens AM1 identified by using transposon mutagenesis including a putative dihydromethanopterin reductase.

Authors:  Christopher J Marx; Brooke N O'Brien; Jennifer Breezee; Mary E Lidstrom
Journal:  J Bacteriol       Date:  2003-01       Impact factor: 3.490

9.  Cofactor contents of methanogenic bacteria reviewed.

Authors:  L G Gorris; C van der Drift
Journal:  Biofactors       Date:  1994-05       Impact factor: 6.113

10.  Application of a Colorimetric Assay to Identify Putative Ribofuranosylaminobenzene 5'-Phosphate Synthase Genes Expressed with Activity in Escherichia coli.

Authors:  Matthew E. Bechard; Sonya Chhatwal; Rosemarie E. Garcia; Madeline E. Rasche
Journal:  Biol Proced Online       Date:  2003-03-04       Impact factor: 3.244
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  11 in total

1.  Discovery and characterization of the first archaeal dihydromethanopterin reductase, an iron-sulfur flavoprotein from Methanosarcina mazei.

Authors:  Sixi Wang; Joane Tiongson; Madeline E Rasche
Journal:  J Bacteriol       Date:  2013-08-30       Impact factor: 3.490

2.  Analysis of gene islands involved in methanopterin-linked C1 transfer reactions reveals new functions and provides evolutionary insights.

Authors:  Marina G Kalyuzhnaya; Natalia Korotkova; Gregory Crowther; Christopher J Marx; Mary E Lidstrom; Ludmila Chistoserdova
Journal:  J Bacteriol       Date:  2005-07       Impact factor: 3.490

3.  Methenyl-Dephosphotetrahydromethanopterin Is a Regulatory Signal for Acclimation to Changes in Substrate Availability in Methylobacterium extorquens AM1.

Authors:  N Cecilia Martinez-Gomez; Nathan M Good; Mary E Lidstrom
Journal:  J Bacteriol       Date:  2015-04-06       Impact factor: 3.490

4.  Novel dephosphotetrahydromethanopterin biosynthesis genes discovered via mutagenesis in Methylobacterium extorquens AM1.

Authors:  Ludmila Chistoserdova; Madeline E Rasche; Mary E Lidstrom
Journal:  J Bacteriol       Date:  2005-04       Impact factor: 3.490

5.  Methylotrophic metabolism is advantageous for Methylobacterium extorquens during colonization of Medicago truncatula under competitive conditions.

Authors:  Abdoulaye Sy; Antonius C J Timmers; Claudia Knief; Julia A Vorholt
Journal:  Appl Environ Microbiol       Date:  2005-11       Impact factor: 4.792

6.  Elucidation of the role of the methylene-tetrahydromethanopterin dehydrogenase MtdA in the tetrahydromethanopterin-dependent oxidation pathway in Methylobacterium extorquens AM1.

Authors:  N Cecilia Martinez-Gomez; Sandy Nguyen; Mary E Lidstrom
Journal:  J Bacteriol       Date:  2013-03-15       Impact factor: 3.490

7.  Methylamine utilization via the N-methylglutamate pathway in Methylobacterium extorquens PA1 involves a novel flow of carbon through C1 assimilation and dissimilation pathways.

Authors:  Dipti D Nayak; Christopher J Marx
Journal:  J Bacteriol       Date:  2014-09-15       Impact factor: 3.490

8.  Flux analysis uncovers key role of functional redundancy in formaldehyde metabolism.

Authors:  Christopher J Marx; Stephen J Van Dien; Mary E Lidstrom
Journal:  PLoS Biol       Date:  2005-01-04       Impact factor: 8.029

9.  Genetic and phenotypic comparison of facultative methylotrophy between Methylobacterium extorquens strains PA1 and AM1.

Authors:  Dipti D Nayak; Christopher J Marx
Journal:  PLoS One       Date:  2014-09-18       Impact factor: 3.240

10.  Global Molecular Analyses of Methane Metabolism in Methanotrophic Alphaproteobacterium, Methylosinus trichosporium OB3b. Part I: Transcriptomic Study.

Authors:  Janet B Matsen; Song Yang; Lisa Y Stein; David Beck; Marina G Kalyuzhnaya
Journal:  Front Microbiol       Date:  2013-04-03       Impact factor: 5.640
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