| Literature DB >> 14972530 |
Li Wu1, Thomas D Martin, Mary Carrington, Vineet N KewalRamani.
Abstract
A number of studies examining interactions of dendritic cell (DC)-specific ICAM-3 grabbing nonintegrin (DC-SIGN) with viral pathogens have relied on monocytic transfectants as models for primary DCs. Here we show that the presumed "THP-1" monocytic cells used in these studies are instead Raji B cells. Moreover, we demonstrate that true THP-1 cells do not support DC-SIGN-mediated HIV-1 transmission, whereas human B cell lines efficiently enhance this process. These data indicate that there are features common to B cells and DCs that facilitate transmission of HIV-1 and provide new insights toward the mechanism of DC-SIGN-mediated HIV-1 transmission.Entities:
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Year: 2004 PMID： 14972530 DOI： 10.1016/j.virol.2003.09.028
Source DB: PubMed Journal: Virology ISSN： 0042-6822 Impact factor: 3.616