Shi-Zhong Chen1, Hui Jia, Yao-Hua Wu, Hong Wang. 1. Laboratory of Traditional Chinese Medicine, Peking University School of Pharmaceutical Sciences, Beijing 100083, China. chenshizhong@vip.sina.com
Abstract
OBJECTIVE: To investigate the pharmacokinetics of honokiol in rats. METHODS: Honokiol injection was delivered by vein injection to SD-rats. The blood samples were gathered at a series of time lags. Honokiol in rat plasma was determined with an RP-HPLC method and the data were analyzed with program 3P87. RESULTS: After i.v. injection of honokiol, concentration-time curves were fitted to a 3-compartment model: with halftime of 2.8 min, 11.9 min, and 56.8 min. CONCLUSION: Honokiol was quickly distributed in rats after i.v. and the concentration decreased rapidly. Our studies provided important referrence to the research on the pharmacodynamics and the pharmaceutics of Honokiol.
OBJECTIVE: To investigate the pharmacokinetics of honokiol in rats. METHODS:Honokiol injection was delivered by vein injection to SD-rats. The blood samples were gathered at a series of time lags. Honokiol in rat plasma was determined with an RP-HPLC method and the data were analyzed with program 3P87. RESULTS: After i.v. injection of honokiol, concentration-time curves were fitted to a 3-compartment model: with halftime of 2.8 min, 11.9 min, and 56.8 min. CONCLUSION:Honokiol was quickly distributed in rats after i.v. and the concentration decreased rapidly. Our studies provided important referrence to the research on the pharmacodynamics and the pharmaceutics of Honokiol.