OBJECTIVE: To investigate the secondary metabolites from Chinese marine Sponge Cinachyrella australiensis. METHODS: Column chromatography techniques including HPLC were used for the separation and purification of the compounds, and extensive spectral analyses including various 2D NMR spectra were employed for structure elucidation. RESULTS: Nineteen compounds were obtained,including 2-methyoxy-6,12,15-trien-8-yne-octadecanoic acid (1), 2-benzenedicarboxylic acid dibutyl ester(2), 1,2-benzenedicarboxylic acid bis(2-ethylhexyl)ester(3), (-) (3S)-1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid(4), L-Tryptophan (5), p-hydroxylbenzaldehyde (6), p-hydroxyl-benzylethanol(7), p-hydroxyl-benzyl-propanol(8), cholesta-4-en-3-ol(9), 2-methyl-6-amino-9-(2-deoxy-beta-D- ribofuranosyl-purine(10), 2'-Deoxyadenosine (11), 6-amino-9-beta-D-ribofuranosyl-9H-purine (12),uracil(13), thymine(14), thymidine(15), 1-(2-deoxy-beta-D-Ribofuranosyl) uracil(16), 1-ethyl-alpha-(2-deoxy)-beta-D-ribofuranos(17),isolumichrome(18),and zarzissine(19). CONCLUSION: Compounds 1 and 18 are new natural products,and compounds 2 to 17 as well as 19 are isolated from this species for the first time.
OBJECTIVE: To investigate the secondary metabolites from Chinese marine Sponge Cinachyrella australiensis. METHODS: Column chromatography techniques including HPLC were used for the separation and purification of the compounds, and extensive spectral analyses including various 2D NMR spectra were employed for structure elucidation. RESULTS: Nineteen compounds were obtained,including 2-methyoxy-6,12,15-trien-8-yne-octadecanoic acid (1), 2-benzenedicarboxylic acid dibutyl ester(2), 1,2-benzenedicarboxylic acid bis(2-ethylhexyl)ester(3), (-) (3S)-1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid(4), L-Tryptophan (5), p-hydroxylbenzaldehyde (6), p-hydroxyl-benzylethanol(7), p-hydroxyl-benzyl-propanol(8), cholesta-4-en-3-ol(9), 2-methyl-6-amino-9-(2-deoxy-beta-D- ribofuranosyl-purine(10), 2'-Deoxyadenosine (11), 6-amino-9-beta-D-ribofuranosyl-9H-purine (12),uracil(13), thymine(14), thymidine(15), 1-(2-deoxy-beta-D-Ribofuranosyl) uracil(16), 1-ethyl-alpha-(2-deoxy)-beta-D-ribofuranos(17),isolumichrome(18),and zarzissine(19). CONCLUSION: Compounds 1 and 18 are new natural products,and compounds 2 to 17 as well as 19 are isolated from this species for the first time.
Authors: Naoya Oku; Kentaro Takada; Richard W Fuller; Jennifer A Wilson; Megan L Peach; Lewis K Pannell; James B McMahon; Kirk R Gustafson Journal: J Am Chem Soc Date: 2010-08-04 Impact factor: 15.419
Authors: Amin Mokhlesi; Rudolf Hartmann; Tibor Kurtán; Horst Weber; Wenhan Lin; Chaidir Chaidir; Werner E G Müller; Georgios Daletos; Peter Proksch Journal: Mar Drugs Date: 2017-11-11 Impact factor: 5.118