| Literature DB >> 14969817 |
Nagaaki Terakado1, Satoru Shintani, Junya Yano, Li Chunnan, Mariko Mihara, Koh-ichi Nakashiro, Hiroyuki Hamakawa.
Abstract
Cyclooxygenase-2 (COX-2), an inducible isoform of cyclooxygenase, is overexpressed in many types of malignant tumors, which in turn may stimulate tumor growth and protect against damage by irradiation or cytotoxic agents. The purpose of this study is to investigate the relationship between the radiation sensitivity and elevated level of COX-2. Radiation sensitivity of the eight oral SCC cell lines differed greatly in their response to radiation. Further, the level of the COX-2 expression correlated inversely with increased tumor radiation sensitivity. The similar significant association between the response to preoperative radiation therapy and COX-2 overexpression was observed in the oral SCC patients. In addition, treatment with a COX-2 selective inhibitor enhanced the radioresponse of HSC-2 cell, which constitutively expressed COX-2. These results suggested that COX-2 expression level correlates to radiation tolerance and the COX-2 selective inhibitor may be a potent enhancer for tumor radioresponse in oral SCC.Entities:
Mesh：
Substances：
Year: 2004 PMID： 14969817 DOI： 10.1016/j.oraloncology.2003.09.005
Source DB: PubMed Journal: Oral Oncol ISSN： 1368-8375 Impact factor: 5.337