| Literature DB >> 14969747 |
Naibedya Chattopadhyay1, Jacob T-Felt Hansen, Madan M Godbole, Edward M Brown.
Abstract
Transforming growth factor beta (TGFbeta) and hepatocyte growth factor (HGF) promote glioma progression. Using U87human astrocytoma cells, which express TGFbeta receptors (TbetaRs), we show (1) mRNA expression of Smads (2, 3, 4), bone morphogenetic protein (BMP)- and activin-A receptors; (2) TGFbeta1 inhibits and HGF induces proliferation; (3) TGFbeta1 and activin-A equipotently inhibit HGF secretion more than BMP-2, but none alters c-Met expression. Because interfering with TbetaR signaling might nullify the beneficial inhibition of HGF secretion, activin-A should instead be considered for combination glioma therapy.Entities:
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Year: 2004 PMID： 14969747 DOI： 10.1016/j.molbrainres.2003.11.008
Source DB: PubMed Journal: Brain Res Mol Brain Res ISSN： 0169-328X