| Literature DB >> 14969745 |
Adrian J Frank1, Roberto Hernan, Andrew Hollander, Janet C Lindsey, Meryl E Lusher, Christine E Fuller, Steven C Clifford, Richard J Gilbertson.
Abstract
We analyzed the TP53 and INK4A/ARF loci in 29 pediatric medulloblastomas. Mutually exclusive mutation in TP53, methylation of P14(ARF) or deletion of INK4A/ARF were identified in 21% (6/29) of tumors. Five of these alterations were detected in large cell/anaplastic medulloblastomas or tumors with significant anaplasia. Our data provide the first evidence that alterations within the TP53-ARF tumor suppressor pathway contribute to development of aggressive forms of medulloblastoma.Entities:
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Year: 2004 PMID： 14969745 DOI： 10.1016/j.molbrainres.2003.11.016
Source DB: PubMed Journal: Brain Res Mol Brain Res ISSN： 0169-328X