Literature DB >> 14969340

Anti-allergic activity of 18beta-glycyrrhetinic acid-3-O-beta-D-glucuronide.

Hae-Young Park1, Sung-Hwan Park, Hae-Kyung Yoon, Myung Joo Han, Dong-Hyun Kim.   

Abstract

Glycyrrhizin (18beta-glycyrrhetinic acid-3-O-beta-D-glucuronopyranosyl-(1 --> 2)-beta-D-glucuronide, GL) was transformed to 18beta-glycyrrhetinic acid-3-O-beta-D-glucuronide (GAMG) by Streptococcus LJ-22. The antiallergic activities of GL and GAMG was measured using a RBL cell assay system and contact hypersensitivity model mice. GAMG exhibited anti-allergic activity with IC50 values of 0.28 mM. GAMG, which is sweeter than GL, and 18beta-glycyrrhetinic acid, which is a GAMG metabolite by human intestinal bacteria, also inhibited the passive cutaneous anaphylaxis and skin contact inflammation. In conclusion, GAMG may be useful as a new sweet food additive and an anti-allergic agent.

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Year:  2004        PMID： 14969340     DOI： 10.1007/bf02980047

Source DB:  PubMed          Journal:  Arch Pharm Res        ISSN： 0253-6269            Impact factor:   4.946


  23 in total

Review 1.  Plant cytochrome P450s: nomenclature and involvement in natural product biosynthesis.

Authors:  Saiema Rasool; Rozi Mohamed
Journal:  Protoplasma       Date:  2015-09-12       Impact factor: 3.356

2.  The Neuroprotective Effect of Glycyrrhizic Acid on an Experimental Model of Focal Cerebral Ischemia in Rats.

Authors:  Tarık Akman; Mustafa Guven; Adem Bozkurt Aras; Adile Ozkan; Halil Murat Sen; Ali Okuyucu; Yildiray Kalkan; Ibrahim Sehitoglu; Coskun Silan; Murat Cosar
Journal:  Inflammation       Date:  2015-08       Impact factor: 4.092

3.  Triterpene functional genomics in licorice for identification of CYP72A154 involved in the biosynthesis of glycyrrhizin.

Authors:  Hikaru Seki; Satoru Sawai; Kiyoshi Ohyama; Masaharu Mizutani; Toshiyuki Ohnishi; Hiroshi Sudo; Ery Odette Fukushima; Tomoyoshi Akashi; Toshio Aoki; Kazuki Saito; Toshiya Muranaka
Journal:  Plant Cell       Date:  2011-11-29       Impact factor: 11.277

4.  A Novel β-Glucuronidase from Talaromyces pinophilus Li-93 Precisely Hydrolyzes Glycyrrhizin into Glycyrrhetinic Acid 3-O-Mono-β-d-Glucuronide.

Authors:  Yinghua Xu; Xudong Feng; Jintong Jia; Xinyi Chen; Tian Jiang; Aamir Rasool; Bo Lv; Liangti Qu; Chun Li
Journal:  Appl Environ Microbiol       Date:  2018-09-17       Impact factor: 4.792

5.  Paeoniflorin, a novel heat shock protein-inducing compound.

Authors:  Dai Yan; Kiyoto Saito; Yuri Ohmi; Noriyo Fujie; Kenzo Ohtsuka
Journal:  Cell Stress Chaperones       Date:  2004       Impact factor: 3.667

6.  Licorice beta-amyrin 11-oxidase, a cytochrome P450 with a key role in the biosynthesis of the triterpene sweetener glycyrrhizin.

Authors:  Hikaru Seki; Kiyoshi Ohyama; Satoru Sawai; Masaharu Mizutani; Toshiyuki Ohnishi; Hiroshi Sudo; Tomoyoshi Akashi; Toshio Aoki; Kazuki Saito; Toshiya Muranaka
Journal:  Proc Natl Acad Sci U S A       Date:  2008-09-08       Impact factor: 11.205

7.  18α-Glycyrrhetinic acid monoglucuronide as an anti-inflammatory agent through suppression of the NF-κB and MAPK signaling pathway.

Authors:  Bo Li; Yongan Yang; Liuzeng Chen; Shichao Chen; Jing Zhang; Wenjian Tang
Journal:  Medchemcomm       Date:  2017-06-02       Impact factor: 3.597

8.  Antioxidant status and immune activity of glycyrrhizin in allergic rhinitis mice.

Authors:  Xiao-Lan Li; Ai-Guo Zhou; Li Zhang; Wei-Jun Chen
Journal:  Int J Mol Sci       Date:  2011-01-26       Impact factor: 5.923

9.  The use of Stronger Neo-Minophagen C, a glycyrrhizin-containing preparation, in robust neuroprotection in the postischemic brain.

Authors:  Seung-Woo Kim; Chae-Moon Lim; Hye-Kyung Lee; Ja-Kyeong Lee
Journal:  Anat Cell Biol       Date:  2011-12-30

Review 10.  Glycyrrhizic acid in the treatment of liver diseases: literature review.

Authors:  Jian-yuan Li; Hong-yan Cao; Ping Liu; Gen-hong Cheng; Ming-yu Sun
Journal:  Biomed Res Int       Date:  2014-05-13       Impact factor: 3.411
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