Jong Weon Choi1, Soo Hwan Pai. 1. Department of Laboratory Medicine, College of Medicine, Inha University Hospital, 7-206, 3-ga, Shinheung-dong, Jung-gu, Inchon 400-711, South Korea. jwchoi@inha.ac.kr
Abstract
BACKGROUND: We investigated whether hypercholesterolemia influenced the values of mean corpuscular volume (MCV) and erythrocyte sedimentation rate (ESR). METHODS: A total of 463 nonanemic elderly persons were evaluated regarding red cell indices, ESR, and ESR-related parameters, such as fibrinogen, albumin, and C-reactive protein (CRP). RESULTS: There were no significant differences in MCV between elderly men with and without hypercholesterolemia (>/=240 mg/dl) nor between the subjects with a marked increase of serum cholesterol concentrations (>/=260 mg/dl) and with severely lowered cholesterol concentrations (<155 mg/dl). ESR in elderly men with hypercholesterolemia averaged 12.3+/-6.8 mm/h, which were significantly higher than in those without hypercholesterolemia (6.0+/-4.7 mm/h, p<0.01). ESR averaged threefold higher in the elderly men with serum cholesterol concentration >/=260 mg/dl versus those with serum cholesterol concentrations <155 mg/dl, although no significant differences were observed in fibrinogen, albumin, and CRP values between the two groups. Serum cholesterol concentrations were higher in elderly men with ESR>/=15.0 mm/h (248.9+/-43.5 mg/dl), compared to those with ESR<2.0 mm/h (199.5+/-31.7 mg/dl, p<0.01). Serum cholesterol concentrations showed no associations with red cell indices but correlated significantly with ESR in elderly men (r=0.24, p<0.01) and postmenopausal women (r=0.21, p<0.01). CONCLUSION: Hypercholesterolemia does not appear to influence MCV but significantly accelerates ESR, especially in elderly men.
BACKGROUND: We investigated whether hypercholesterolemia influenced the values of mean corpuscular volume (MCV) and erythrocyte sedimentation rate (ESR). METHODS: A total of 463 nonanemic elderly persons were evaluated regarding red cell indices, ESR, and ESR-related parameters, such as fibrinogen, albumin, and C-reactive protein (CRP). RESULTS: There were no significant differences in MCV between elderly men with and without hypercholesterolemia (>/=240 mg/dl) nor between the subjects with a marked increase of serum cholesterol concentrations (>/=260 mg/dl) and with severely lowered cholesterol concentrations (<155 mg/dl). ESR in elderly men with hypercholesterolemia averaged 12.3+/-6.8 mm/h, which were significantly higher than in those without hypercholesterolemia (6.0+/-4.7 mm/h, p<0.01). ESR averaged threefold higher in the elderly men with serum cholesterol concentration >/=260 mg/dl versus those with serum cholesterol concentrations <155 mg/dl, although no significant differences were observed in fibrinogen, albumin, and CRP values between the two groups. Serum cholesterol concentrations were higher in elderly men with ESR>/=15.0 mm/h (248.9+/-43.5 mg/dl), compared to those with ESR<2.0 mm/h (199.5+/-31.7 mg/dl, p<0.01). Serum cholesterol concentrations showed no associations with red cell indices but correlated significantly with ESR in elderly men (r=0.24, p<0.01) and postmenopausal women (r=0.21, p<0.01). CONCLUSION:Hypercholesterolemia does not appear to influence MCV but significantly accelerates ESR, especially in elderly men.
Authors: Fatih Celal Alcicek; Tasnim Mohaissen; Katarzyna Bulat; Jakub Dybas; Ewa Szczesny-Malysiak; Magdalena Kaczmarska; Magdalena Franczyk-Zarow; Renata Kostogrys; Katarzyna M Marzec Journal: Front Physiol Date: 2022-02-18 Impact factor: 4.566