Literature DB >> 14965243

5-HT4 receptors.

J Bockaert1, S Claeysen, V Compan, A Dumuis.   

Abstract

Serotonin 4 receptors (5-HT(4)Rs) were discovered 15 years ago. They are coded by a very complex gene (700Kb, 38 exons) which generates eight carboxy-terminal variants (a, b, c, d, e, f, g, n). Their sequences differ after position L(358). Another variant is characterized by a 14 residue insertion within the extracellular loop 2. Highly selective potent 5-HT(4) receptor antagonists and partial agonists which cross the blood-brain barrier have been synthesized, but a specific full agonist for brain studies is still missing. Based on physiological and behavioral experiments, 5-HT(4)Rs may be targets to treat cognitive deficits, abdominal pain and feeding disorders. One 5-HT(4)R-directed drug (SL65.0155) is already in phase II to treat patients suffering from memory deficits or dementia.

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Year:  2004        PMID： 14965243     DOI： 10.2174/1568007043482615

Source DB:  PubMed          Journal:  Curr Drug Targets CNS Neurol Disord        ISSN： 1568-007X


  40 in total

Review 1.  Serotonin receptor signaling and regulation via β-arrestins.

Authors:  Laura M Bohn; Cullen L Schmid
Journal:  Crit Rev Biochem Mol Biol       Date:  2010-10-07       Impact factor: 8.250

Review 2.  PET tracers for serotonin receptors and their applications.

Authors:  J S Dileep Kumar; J John Mann
Journal:  Cent Nerv Syst Agents Med Chem       Date:  2014

3.  Synaptic plasticity in myenteric neurons of the guinea-pig distal colon: presynaptic mechanisms of inflammation-induced synaptic facilitation.

Authors:  Eric M Krauter; David R Linden; Keith A Sharkey; Gary M Mawe
Journal:  J Physiol       Date:  2007-03-15       Impact factor: 5.182

4.  Inhibition of colonic motility and defecation by RS-127445 suggests an involvement of the 5-HT2B receptor in rodent large bowel physiology.

Authors:  A K Bassil; C M Taylor; V J N Bolton; K M Gray; J D Brown; L Cutler; S G Summerfield; G Bruton; W J Winchester; K Lee; G J Sanger
Journal:  Br J Pharmacol       Date:  2009-04-09       Impact factor: 8.739

Review 5.  Alzheimer's disease and age-related memory decline (preclinical).

Authors:  Alvin V Terry; Patrick M Callahan; Brandon Hall; Scott J Webster
Journal:  Pharmacol Biochem Behav       Date:  2011-02-24       Impact factor: 3.533

6.  Age and sex effects on 5-HT(4) receptors in the human brain: a [(11)C]SB207145 PET study.

Authors:  Karine Madsen; Mette T Haahr; Lisbeth Marner; Sune H Keller; William F Baaré; Claus Svarer; Steen G Hasselbalch; Gitte M Knudsen
Journal:  J Cereb Blood Flow Metab       Date:  2011-03-02       Impact factor: 6.200

7.  Rapid anxiolytic effects of a 5-HT₄ receptor agonist are mediated by a neurogenesis-independent mechanism.

Authors:  Indira Mendez-David; Denis J David; Flavie Darcet; Melody V Wu; Saadia Kerdine-Römer; Alain M Gardier; René Hen
Journal:  Neuropsychopharmacology       Date:  2013-11-28       Impact factor: 7.853

Review 8.  The serotonin 5-HT7 receptors: two decades of research.

Authors:  Evelien Gellynck; Karen Heyninck; Kjetil W Andressen; Guy Haegeman; Finn Olav Levy; Peter Vanhoenacker; Kathleen Van Craenenbroeck
Journal:  Exp Brain Res       Date:  2013-09-17       Impact factor: 1.972

Review 9.  Association of Serotonin Receptors with Attention Deficit Hyperactivity Disorder: A Systematic Review and Meta-analysis.

Authors:  Yu-Wei Hou; Ping Xiong; Xue Gu; Xin Huang; Min Wang; Jing Wu
Journal:  Curr Med Sci       Date:  2018-06-22

Review 10.  Serotonin 1A and Serotonin 4 Receptors: Essential Mediators of the Neurogenic and Behavioral Actions of Antidepressants.

Authors:  Benjamin Adam Samuels; Indira Mendez-David; Charlène Faye; Sylvain André David; Kerri A Pierz; Alain M Gardier; René Hen; Denis J David
Journal:  Neuroscientist       Date:  2014-12-08       Impact factor: 7.519
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