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Literature DB >> 1496402

Activation of transcription factors by interferon-alpha in a cell-free system.

Abstract

The signal transduction mechanisms of interferons (IFNs) remain unclear partly because no effect of IFN has been reproducible in a cell-free system. IFN-alpha rapidly induces the transcription of a set of early response genes, and a multicomponent transcriptional activator, interferon stimulated gene factor 3 (ISGF3), is activated within minutes after binding of IFN-alpha to its receptor. A system was developed in which IFN-alpha activated ISGF3 in homogenates of HeLa cells. Subcellular fractionation revealed that incubation of a plasma membrane-enriched fraction with IFN-alpha was sufficient to activate the regulatory subcomponent of ISGF3.

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Year: 1992 PMID： 1496402 DOI： 10.1126/science.1496402

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

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Cited

16 in total

1. Role of protein kinase C in the inhibitory action of trophoblast interferons on expression of the oxytocin receptor in sheep endometrium.

Authors: D R Abayasekara; E L Sheldrick; H C Flick-Smith; A P Flint
Journal: Endocrine Date: 1995-02 Impact factor: 3.633

2. Direct binding to and tyrosine phosphorylation of the alpha subunit of the type I interferon receptor by p135tyk2 tyrosine kinase.

Authors: O Colamonici; H Yan; P Domanski; R Handa; D Smalley; J Mullersman; M Witte; K Krishnan; J Krolewski
Journal: Mol Cell Biol Date: 1994-12 Impact factor: 4.272

3. In vitro activation of the transcription factor gamma interferon activation factor by gamma interferon: evidence for a tyrosine phosphatase/kinase signaling cascade.

Authors: K Igarashi; M David; D S Finbloom; A C Larner
Journal: Mol Cell Biol Date: 1993-03 Impact factor: 4.272

4. Ligand-dependent and -independent activation of the transcription factor gamma RF-1 in a cell-free system.

Authors: C A Feghali; T M Wright
Journal: Biochem J Date: 1995-09-01 Impact factor: 3.857

5. In vitro activation of a transcription factor by gamma interferon requires a membrane-associated tyrosine kinase and is mimicked by vanadate.

Authors: K Igarashi; M David; A C Larner; D S Finbloom
Journal: Mol Cell Biol Date: 1993-07 Impact factor: 4.272

6. The genomic structure of the murine ICSBP gene reveals the presence of the gamma interferon-responsive element, to which an ISGF3 alpha subunit (or similar) molecule binds.

Authors: Y Kanno; C A Kozak; C Schindler; P H Driggers; D L Ennist; S L Gleason; J E Darnell; K Ozato
Journal: Mol Cell Biol Date: 1993-07 Impact factor: 4.272

7. The interleukin-6-activated acute-phase response factor is antigenically and functionally related to members of the signal transducer and activator of transcription (STAT) family.

Authors: U M Wegenka; C Lütticken; J Buschmann; J Yuan; F Lottspeich; W Müller-Esterl; C Schindler; E Roeb; P C Heinrich; F Horn
Journal: Mol Cell Biol Date: 1994-05 Impact factor: 4.272