| Literature DB >> 14963172 |
Su-Jun Deng1, Kenneth H Pearce, Eric P Dixon, Kelly A Hartley, Thomas B Stanley, David C Lobe, Edward P Garvey, Thomas A Kost, Regina L Petty, Warren J Rocque, Kenneth A Alexander, Mark R Underwood.
Abstract
Peptide antagonists of the human papillomavirus type 11 (HPV-11) E2-DNA association were identified using a filamentous bacteriophage random peptide library. Synthetic peptides antagonized the E2-DNA interaction, effectively blocked E2-mediated transcriptional activation of a reporter gene in cell culture, and inhibited E1-E2-mediated HPV-11 DNA replication in vitro. These peptides may prove to be useful tools for characterizing E2 function and for exploring the effectiveness of E2-inhibitor-based treatments for HPV-associated diseases.Entities:
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Year: 2004 PMID： 14963172 PMCID： PMC369253 DOI： 10.1128/jvi.78.5.2637-2641.2003
Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103