Literature DB >> 14961695

A convenient new synthesis of benzo[a]pyrene.

Ronald G Harvey1, Keunpoong Lim, Qing Dai.   

Abstract

A convenient new synthesis of the ubiquitous environmental carcinogen benzo[a]pyrene (BaP) is described. In the key step, the method entails Suzuki coupling of naphthalene 2-boronic acid with 2-bromobenzene-1,3-dialdehyde and requires only three steps. It is considerably shorter and simpler than the older methods and provides BaP in higher overall yield.

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Year:  2004        PMID: 14961695     DOI: 10.1021/jo030313n

Source DB:  PubMed          Journal:  J Org Chem        ISSN: 0022-3263            Impact factor:   4.354


  2 in total

1.  Synthesis of 13C2-Benzo[a]pyrene and its 7,8-Dihydrodiol and 7,8-Dione Implicated as Carcinogenic Metabolites.

Authors:  Chongzhao Ran; Daiwang Xu; Qing Dai; Trevor M Penning; Ian A Blair; Ronald G Harvey
Journal:  Tetrahedron Lett       Date:  2008-07-21       Impact factor: 2.415

2.  Synthesis of phenol and quinone metabolites of benzo[a]pyrene, a carcinogenic component of tobacco smoke implicated in lung cancer.

Authors:  Daiwang Xu; Trevor M Penning; Ian A Blair; Ronald G Harvey
Journal:  J Org Chem       Date:  2009-01-16       Impact factor: 4.354

  2 in total

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