Literature DB >> 14960303

ERK-1/2 activity is required for efficient RSV infection.

Xiaoyuan Kong1, Homero San Juan, Aruna Behera, Mark E Peeples, Jerry Wu, Richard F Lockey, Shyam S Mohapatra.   

Abstract

Respiratory syncytial virus (RSV) infection up-regulates the expression of genes encoding proinflammatory mediators in bronchial epithelial cells. However, the specific signaling events immediately following RSV exposure are poorly understood. Herein, we report that RSV attachment to A549 cells activates both ERK-1 and ERK-2 pathways within 5 min. Inhibition of ERK pathways significantly decreases RSV infection of these cells compared to controls. These results demonstrate that the activation of the ERK-1/2 is required in RSV-induced early gene expression.

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Year:  2004        PMID： 14960303     DOI： 10.1016/S0014-5793(04)00002-X

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  24 in total

1.  Mechanism of sustained activation of ribosomal S6 kinase (RSK) and ERK by kaposi sarcoma-associated herpesvirus ORF45: multiprotein complexes retain active phosphorylated ERK AND RSK and protect them from dephosphorylation.

Authors:  Ersheng Kuang; Fayi Wu; Fanxiu Zhu
Journal:  J Biol Chem       Date:  2009-03-20       Impact factor: 5.157

2.  Localization of ERK/MAP kinase is regulated by the alphaherpesvirus tegument protein Us2.

Authors:  Mathew G Lyman; Jessica A Randall; Christine M Calton; Bruce W Banfield
Journal:  J Virol       Date:  2006-07       Impact factor: 5.103

3.  ERK1/2 and MEK1/2 induced by Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) early during infection of target cells are essential for expression of viral genes and for establishment of infection.

Authors:  Neelam Sharma-Walia; Harinivas H Krishnan; Pramod P Naranatt; Ling Zeng; Marilyn S Smith; Bala Chandran
Journal:  J Virol       Date:  2005-08       Impact factor: 5.103

4.  Protein kinase C-alpha activity is required for respiratory syncytial virus fusion to human bronchial epithelial cells.

Authors:  Homero San-Juan-Vergara; Mark E Peeples; Richard F Lockey; Shyam S Mohapatra
Journal:  J Virol       Date:  2004-12       Impact factor: 5.103

5.  Suppression of coronavirus replication by inhibition of the MEK signaling pathway.

Authors:  Yingyun Cai; Yin Liu; Xuming Zhang
Journal:  J Virol       Date:  2006-11-01       Impact factor: 5.103

Review 6.  Structure and function of respiratory syncytial virus surface glycoproteins.

Authors:  Jason S McLellan; William C Ray; Mark E Peeples
Journal:  Curr Top Microbiol Immunol       Date:  2013       Impact factor: 4.291

7.  Activated Ras/MEK inhibits the antiviral response of alpha interferon by reducing STAT2 levels.

Authors:  Sherri L Christian; Thaddeus W Collier; Dong Zu; Maria Licursi; Chris M Hough; Kensuke Hirasawa
Journal:  J Virol       Date:  2009-04-22       Impact factor: 5.103

Review 8.  Epidemiologic, experimental, and clinical links between respiratory syncytial virus infection and asthma.

Authors:  Shyam S Mohapatra; Sandhya Boyapalle
Journal:  Clin Microbiol Rev       Date:  2008-07       Impact factor: 26.132

9.  Protease-activated receptor 1 inhibition protects mice against thrombin-dependent respiratory syncytial virus and human metapneumovirus infections.

Authors:  Vuong Ba Lê; Béatrice Riteau; Marie-Christine Alessi; Christian Couture; Martine Jandrot-Perrus; Chantal Rhéaume; Marie-Ève Hamelin; Guy Boivin
Journal:  Br J Pharmacol       Date:  2017-12-10       Impact factor: 8.739

10.  Differential regulation of type I interferon and epidermal growth factor pathways by a human Respirovirus virulence factor.

Authors:  Grégory Caignard; Anastassia V Komarova; Mehdi Bouraï; Thomas Mourez; Yves Jacob; Louis M Jones; Flore Rozenberg; Astrid Vabret; François Freymuth; Frédéric Tangy; Pierre-Olivier Vidalain
Journal:  PLoS Pathog       Date:  2009-09-18       Impact factor: 6.823
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