| Literature DB >> 1495905 |
B Steffan1, W Fischer, G Cordes, I Habon, R Müller.
Abstract
Prostaglandin E1 is currently marketed as a freeze-dried injectable inclusion complex with alpha-cyclodextrin for the treatment of peripheral arterial diseases. alpha-Cyclodextrin is used as a stabilizing agent and to improve the dissolution characteristics of prostaglandin E1. Upon dilution with the infusion medium, the inclusion complex dissociates almost completely as shown by NMR chemical shift measurements of the complexed and uncomplexed prostaglandin E1. Nuclear Overhauser effect (NOE) measurements of the interacting atoms of alpha-cyclodextrin and prostaglandin E1 provide insight into the structure of the complex.Entities:
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Year: 1992 PMID： 1495905 DOI： 10.1023/a:1015865002470
Source DB: PubMed Journal: Pharm Res ISSN： 0724-8741 Impact factor: 4.200