| Literature DB >> 1495752 |
A Hagiwara1, T Takahashi, T Sasabe, M Ito, M Lee, C Sakakura, S Shoubayashi, S Tashima, S Muranishi.
Abstract
Etoposide microcrystals suspended in oil (ETOP-OIL) were examined for their therapeutic effects on peritoneal carcinomatosis in mice. Two days after intraperitoneal inoculation with 10(5) P388 leukemia cells/mouse to CDF1 male mice, etoposide at 10-80 mg/kg was administered intraperitoneally in bolus in the form of ETOP-OIL or in the aqueous solution form. In every dose, the survival curve of the mice given ETOP-OIL was statistically significantly improved in spite of its small lethal toxicity, as compared with those given the identical dose of etoposide aqueous solution.Entities:
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Year: 1992 PMID： 1495752 DOI： 10.1159/000227046
Source DB: PubMed Journal: Oncology ISSN： 0030-2414 Impact factor: 2.935