Literature DB >> 149439

In vivo DNA repair after N-methyl-N-nitrosourea administration to rats of different ages.

G Arfellini, S Grilli, G Prodi.   

Abstract

DNA repair time-course was studied after injury by N-methyl-N-nitrosourea (MNU) in rat liver cells of animals of different ages and in fetuses using hydroxyurea (HU) as inhibitor of scheduled DNA synthesis. DNA repair was a rapid phenomenon, more so in young adults than in newborns, and was not detectable in fetuses. A correlation seems to exist among organ sensitivity to carcinogen, age of animal and DNA repair.

Entities:  

Mesh：

Substances：

Year:  1978        PMID： 149439     DOI： 10.1007/bf00284022

Source DB:  PubMed          Journal:  Z Krebsforsch Klin Onkol Cancer Res Clin Oncol        ISSN： 0084-5353


  20 in total

1.  Suggestive evidence for relationship between sensitivity and repair capability in rat ascites hepatoma cells treated with the antitumor agent, 1-(gamma-chloropropyl)-2-chloromethylpiperidine hydrobromide.

Authors:  S Fukuda; R Koshiura; K Miyamoto; M Hatano
Journal:  Gan       Date:  1977-04

2.  Two forms of repair in the DNA of human cells damaged by chemical carcinogens and mutagens.

Authors:  J D Regan; R B Setlow
Journal:  Cancer Res       Date:  1974-12       Impact factor: 12.701

3.  Carcinogenicity of N-methyl-N-nitrosourea: possible role of excision repair of O6-methylguanine from DNA.

Authors:  P Kleihues; G P Margison
Journal:  J Natl Cancer Inst       Date:  1974-12       Impact factor: 13.506

4.  Carcinogenesis and alkylation of rat liver nucleic acids by nitrosomethylurea and nitrosoethylurea administered by intraportal injection.

Authors:  W Lijinsky; H Garcia; L Keefer; J Loo; A E Ross
Journal:  Cancer Res       Date:  1972-05       Impact factor: 12.701

5.  [Blockage of DNA synthesis by N-methyl-N-nitrososurea in vivo].

Authors:  P Kleihues
Journal:  Arzneimittelforschung       Date:  1969-07

6.  Synchronisation in vivo: kinetics of a malignant cell system following temporary inhibition of DNA synthesis with hydroxyurea.

Authors:  M F Rajewsky
Journal:  Exp Cell Res       Date:  1970-05       Impact factor: 3.905

7.  A description of two procedures which avoid the use of extreme pH conditions for the resolution of components isolated from chromatins prepared from pig cerebellar and pituitary nuclei.

Authors:  L M Shaw; R C Huang
Journal:  Biochemistry       Date:  1970-11-10       Impact factor: 3.162

8.  Removal of 5-bromo-2-deoxyuridine incorporated in DNA of regenerating rat liver.

Authors:  G Arfellini; G Prodi; S Grilli
Journal:  Nature       Date:  1977-01-27       Impact factor: 49.962

9.  Chemical carcinogenesis in the nervous system. Preferential accumulation of O6-methylguanine in rat brain deoxyribonucleic acid during repetitive administration of N-methyl-N-nitrosourea.

Authors:  G P Margison; P Kleihues
Journal:  Biochem J       Date:  1975-06       Impact factor: 3.857

10.  Carcinogenicity of a single administration of N-nitrosomethylurea: a comparison between newborn and 5-week-old mice and rats.

Authors:  B Terracini; M C Testa
Journal:  Br J Cancer       Date:  1970-09       Impact factor: 7.640
View more
  1 in total

Review 1.  Critical windows of exposure for children's health: cancer in human epidemiological studies and neoplasms in experimental animal models.

Authors:  L M Anderson; B A Diwan; N T Fear; E Roman
Journal:  Environ Health Perspect       Date:  2000-06       Impact factor: 9.031
  1 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.