Chromatographic methods of analysis for penicillins in food-animal tissues and their significance in regulatory programs for residue reduction and avoidance.

Chromatographic methods for penicillin analysis in animal tissues play a significant role in the regulation of the use of these drugs in livestock production. Regulatory agencies rely on data generated from these methods to establish withdrawal times and to determine whether presumptive positive tissue samples from slaughtered animals intended for human consumption contain violative levels of penicillins to necessitate regulatory action. The need to develop sensitive, accurate, and reliable methods to support regulatory programs is examined together with emerging techniques that could be taken advantage of to improve the sensitivity and usefulness of current chromatographic methods for tomorrow's regulatory agency.