Literature DB >> 1494

Determination of low cencentrations of the quaternary ammonium compound thiazinamium methylsulphate in plasma and urine.

J G Jonkman, J Wijsbeek, S Hollenbeek, S H de Boer, R A de Zeeuw, L E Van Bork, N G Orie.   

Abstract

A sensitive and selective method for the quantitative determination of the quaternary ammonium antiacetylcholine-compound thiazinamium methylsulphate (Multergan) in plasma and urine is described. The procedure is based on ion pair extraction of the compound with iodide as the counter ion. This is followed by gas chromatography using an alkali flame ionization detector. The detection limit is 2 ng ml-1 with a recovery of 88-0 +/- 6-2% from plasma, 91-4 +/- 4-6% from urine. The described method can also be applied to other quaternary ammonium compounds.

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Year:  1975        PMID： 1494     DOI： 10.1111/j.2042-7158.1975.tb10228.x

Source DB:  PubMed          Journal:  J Pharm Pharmacol        ISSN： 0022-3573            Impact factor:   3.765


  5 in total

1.  Pharmacokinetics of diphemanil methylsulphate in healthy subjects.

Authors:  A M Vidal; E Rey; G Pons; J Y Pello; P d'Athis; G Olive
Journal:  Eur J Clin Pharmacol       Date:  1992       Impact factor: 2.953

2.  Molecular modeling and molecular dynamics simulation studies on thyroid hormone receptor from Rattus norvegicus: role of conserved water molecules.

Authors:  Soumita Mukherjee; Subrata Dasgupta; Utpal Adhikari; Sujit Sankar Panja
Journal:  J Mol Model       Date:  2021-04-08       Impact factor: 1.810

3.  Metabolism and excretion of the quaternary ammonium compound thiazinamium methylsulfate (Multergan) in man. I. Parenteral administration.

Authors:  J H Jonkman; J Wijsbeek; R A De Zeeuw; L E Van Bork; N G Orie; A M Soeterboek; J Bender
Journal:  Pharm Weekbl Sci       Date:  1982-10-22

4.  Pharmacokinetics and pharmacodynamics of thiazinamium in asthmatic patients.

Authors:  N H Holford; P Clements; P Collier; N G Orie; L E van Bork; J H Jonkman
Journal:  Eur J Clin Pharmacol       Date:  1987       Impact factor: 2.953

5.  Evaluation of the anticholinergic actions of glycopyrronium bromide.

Authors:  R K Mirakhur; J W Dundee; C J Jones
Journal:  Br J Clin Pharmacol       Date:  1978-01       Impact factor: 4.335
  5 in total

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