Literature DB >> 1492367

Creation of immunoglobulin diversity by intrachromosomal gene conversion.

C B Thompson1.   

Abstract

Not all vertebrates create an immunoglobulin repertoire through the recombination of individual members of variable (V), diversity (D) and joining (J) gene segment families. In chickens, for example, a diverse set of immunoglobulins is created by intrachromosomal gene conversion of the single variable gene segments of the immunoglobulin heavy and light chain genes. Recent evidence from other species such as the rabbit suggests that gene conversion may be a more widespread mechanism for the creation of immunologic diversity than previously supposed.

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Year:  1992        PMID： 1492367     DOI： 10.1016/0168-9525(92)90324-w

Source DB:  PubMed          Journal:  Trends Genet        ISSN： 0168-9525            Impact factor:   11.639


  9 in total

Review 1.  Homologous genetic recombination as an intrinsic dynamic property of a DNA structure induced by RecA/Rad51-family proteins: a possible advantage of DNA over RNA as genomic material.

Authors:  T Shibata; T Nishinaka; T Mikawa; H Aihara; H Kurumizaka; S Yokoyama; Y Ito
Journal:  Proc Natl Acad Sci U S A       Date:  2001-07-17       Impact factor: 11.205

2.  The antigen-binding characteristics of mAbs derived from in vivo priming of avian B cells.

Authors:  N Michael; M A Accavitti; E Masteller; C B Thompson
Journal:  Proc Natl Acad Sci U S A       Date:  1998-02-03       Impact factor: 11.205

3.  New rust resistance specificities associated with recombination in the Rp1 complex in maize.

Authors:  T E Richter; T J Pryor; J L Bennetzen; S H Hulbert
Journal:  Genetics       Date:  1995-09       Impact factor: 4.562

Review 4.  Gene conversion in the chicken immunoglobulin locus: a paradigm of homologous recombination in higher eukaryotes.

Authors:  O Y Bezzubova; J M Buerstedde
Journal:  Experientia       Date:  1994-03-15

5.  Identification of a chicken RAD52 homologue suggests conservation of the RAD52 recombination pathway throughout the evolution of higher eukaryotes.

Authors:  O Y Bezzubova; H Schmidt; K Ostermann; W D Heyer; J M Buerstedde
Journal:  Nucleic Acids Res       Date:  1993-12-25       Impact factor: 16.971

6.  An efficient method to generate chromosomal rearrangements by targeted DNA double-strand breaks in Drosophila melanogaster.

Authors:  Dieter Egli; Ernst Hafen; Walter Schaffner
Journal:  Genome Res       Date:  2004-06-14       Impact factor: 9.043

7.  Nonrepresentative PCR amplification of variable gene sequences in clinical specimens containing dilute, complex mixtures of microorganisms.

Authors:  C J Wright; A E Jerse; M S Cohen; J G Cannon; H S Seifert
Journal:  J Clin Microbiol       Date:  1994-02       Impact factor: 5.948

8.  Mutations in the human lambda5/14.1 gene result in B cell deficiency and agammaglobulinemia.

Authors:  Y Minegishi; E Coustan-Smith; Y H Wang; M D Cooper; D Campana; M E Conley
Journal:  J Exp Med       Date:  1998-01-05       Impact factor: 14.307

9.  Concerted evolution of the tandem array encoding primate U2 snRNA occurs in situ, without changing the cytological context of the RNU2 locus.

Authors:  T Pavelitz; L Rusché; A G Matera; J M Scharf; A M Weiner
Journal:  EMBO J       Date:  1995-01-03       Impact factor: 11.598
  9 in total

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