Literature DB >> 1492120

Pokeweed antiviral protein: ribosome inactivation and therapeutic applications.

J D Irvin1, F M Uckun.   

Abstract

Pokeweed antiviral protein (PAP) is a ribosome-inactivating protein (RIP) that inactivates ribosomes by the removal of a single adenine from ribosomal RNA. The studies summarized in our review concern the nature and application of this novel therapeutic agent. We describe how researchers continue to elucidate the structure and biologic activity of RIPs. Pokeweed antiviral protein is among the RIPs that have been conjugated to selective monoclonal antibodies for the treatment of several human cancers and viral diseases. Clinical trials using PAP immunotoxins for the treatment of leukemia have been particularly encouraging.

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Year:  1992        PMID： 1492120     DOI： 10.1016/0163-7258(92)90053-3

Source DB:  PubMed          Journal:  Pharmacol Ther        ISSN： 0163-7258            Impact factor:   12.310


  27 in total

1.  GnRH-PAP hormonotoxin targets cytotoxicity to prostate cancer cell lines.

Authors:  Lin Qi; Terry M Nett; Matthew C Allen; Xiaoming Sha; Gail S Harrison; Barbara A Frederick; L Michael Glode
Journal:  Urol Res       Date:  2003-09-13

2.  X-ray crystallographic analysis of the structural basis for the interaction of pokeweed antiviral protein with guanine residues of ribosomal RNA.

Authors:  I V Kurinov; F Rajamohan; T K Venkatachalam; F M Uckun
Journal:  Protein Sci       Date:  1999-11       Impact factor: 6.725

3.  Ribosomal protein L3: gatekeeper to the A site.

Authors:  Arturas Meskauskas; Jonathan D Dinman
Journal:  Mol Cell       Date:  2007-03-23       Impact factor: 17.970

4.  Protoplasts from Phytolacca dodecandra L'Herit (endod) and P. americana L. (pokeweed).

Authors:  P E Koch; M S Bonness; H Lu; T J Mabry
Journal:  Plant Cell Rep       Date:  1996-08       Impact factor: 4.570

5.  Reduced toxicity and broad spectrum resistance to viral and fungal infection in transgenic plants expressing pokeweed antiviral protein II.

Authors:  P Wang; O Zoubenko; N E Tumer
Journal:  Plant Mol Biol       Date:  1998-12       Impact factor: 4.076

Review 6.  Immunotoxins for the treatment of B-cell lymphomas.

Authors:  M A Ghetie; V Ghetie; E S Vitetta
Journal:  Mol Med       Date:  1997-07       Impact factor: 6.354

7.  A novel mechanism for inhibition of translation by pokeweed antiviral protein: depurination of the capped RNA template.

Authors:  K A Hudak; P Wang; N E Tumer
Journal:  RNA       Date:  2000-03       Impact factor: 4.942

8.  Eukaryotic elongation factor 2 can bind to the synthetic oligoribonucleotide that mimics sarcin/ricin domain of rat 28S ribosomal RNA.

Authors:  S Tang; W J He; H Xu; W Y Liu; K C Ruan
Journal:  Mol Cell Biochem       Date:  2001-07       Impact factor: 3.396

Review 9.  Vaginal microbicides: a novel approach to preventing sexual transmission of HIV.

Authors:  Gustavo Doncel; Christine Mauck
Journal:  Curr HIV/AIDS Rep       Date:  2004-04       Impact factor: 5.071

10.  Pokeweed antiviral protein depurinates the sarcin/ricin loop of the rRNA prior to binding of aminoacyl-tRNA to the ribosomal A-site.

Authors:  Sheila Mansouri; Emad Nourollahzadeh; Katalin A Hudak
Journal:  RNA       Date:  2006-08-03       Impact factor: 4.942
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