Literature DB >> 1492095

Improved detection of homology in distantly related proteins: similarity of adducin with actin-binding proteins.

G Simon1, R Paladini, S Tisminetzky, M Cserzö, Z Hátsági, A Tossi, S Pongor.   

Abstract

A novel and generally applicable method is described for the detection of homology in distantly related proteins using a new domain sequence database that contains over 20,000 protein sequence segments of known function. The use of the method is illustrated on distantly related domains shared by complement components C1S and C1R, calcium-dependent serine proteinase and bone morphogenetic protein 1. New homologies are shown between human adducin and the actin-binding domains of alfa-actinin and dystrophin.

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Year:  1992        PMID： 1492095

Source DB:  PubMed          Journal:  Protein Seq Data Anal        ISSN： 0931-9506


  2 in total

1.  The SBASE protein domain library, release 2.0: a collection of annotated protein sequence segments.

Authors:  S Pongor; V Skerl; M Cserzö; Z Hátsági; G Simon; V Bevilacqua
Journal:  Nucleic Acids Res       Date:  1993-07-01       Impact factor: 16.971

2.  The SBASE domain sequence resource, release 12: prediction of protein domain-architecture using support vector machines.

Authors:  Kristian Vlahovicek; László Kaján; Vilmos Agoston; Sándor Pongor
Journal:  Nucleic Acids Res       Date:  2005-01-01       Impact factor: 16.971
  2 in total

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