Literature DB >> 1491781

Thrombin accumulation in brains of patients with Alzheimer's disease.

H Akiyama1, K Ikeda, H Kondo, P L McGeer.   

Abstract

Thrombin was detected immunohistochemically in brain tissue of Alzheimer's disease (AD) patients and age-matched controls. Positive staining was restricted to vessels and residual plasma in controls but was also present in senile plaques, some diffuse amyloid deposits and neurofibrillary tangles in AD. Positive staining was abolished by absorption of antibody with purified human thrombin but not by absorption with prothrombin. The data suggest that thrombin formation from prothrombin probably takes place in AD brain.

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Year:  1992        PMID： 1491781     DOI： 10.1016/0304-3940(92)90065-f

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  37 in total

1.  Prothrombin concentration in the cerebrospinal fluid is not altered in Alzheimer's disease.

Authors:  P Lewczuk; J Wiltfang; M Lange; H Jahn; H Reiber; H Ehrenreich
Journal:  Neurochem Res       Date:  1999-12       Impact factor: 3.996

Review 2.  Protease-activated receptors: regulation of neuronal function.

Authors:  Toshiyuki Saito; Nigel W Bunnett
Journal:  Neuromolecular Med       Date:  2005       Impact factor: 3.843

3.  Thrombin induces apoptosis in cultured neurons and astrocytes via a pathway requiring tyrosine kinase and RhoA activities.

Authors:  F M Donovan; C J Pike; C W Cotman; D D Cunningham
Journal:  J Neurosci       Date:  1997-07-15       Impact factor: 6.167

4.  Evidence of angiogenic vessels in Alzheimer's disease.

Authors:  Brinda S Desai; Julie A Schneider; Jia-Liang Li; Paul M Carvey; Bill Hendey
Journal:  J Neural Transm (Vienna)       Date:  2009-04-16       Impact factor: 3.575

5.  Aptamer-functionalized microgel particles for protein detection.

Authors:  Rathi L Srinivas; Stephen C Chapin; Patrick S Doyle
Journal:  Anal Chem       Date:  2011-11-07       Impact factor: 6.986

Review 6.  Inflammation and Alzheimer's disease.

Authors:  H Akiyama; S Barger; S Barnum; B Bradt; J Bauer; G M Cole; N R Cooper; P Eikelenboom; M Emmerling; B L Fiebich; C E Finch; S Frautschy; W S Griffin; H Hampel; M Hull; G Landreth; L Lue; R Mrak; I R Mackenzie; P L McGeer; M K O'Banion; J Pachter; G Pasinetti; C Plata-Salaman; J Rogers; R Rydel; Y Shen; W Streit; R Strohmeyer; I Tooyoma; F L Van Muiswinkel; R Veerhuis; D Walker; S Webster; B Wegrzyniak; G Wenk; T Wyss-Coray
Journal:  Neurobiol Aging       Date:  2000 May-Jun       Impact factor: 4.673

7.  Inhibition of Src family kinases improves cognitive function after intraventricular hemorrhage or intraventricular thrombin.

Authors:  Da Zhi Liu; Ben Waldau; Bradley P Ander; Xinhua Zhan; Boryana Stamova; Glen C Jickling; Bruce G Lyeth; Frank R Sharp
Journal:  J Cereb Blood Flow Metab       Date:  2016-01-01       Impact factor: 6.200

Review 8.  Cell cycle inhibition without disruption of neurogenesis is a strategy for treatment of central nervous system diseases.

Authors:  Da-Zhi Liu; Bradley P Ander; Frank R Sharp
Journal:  Neurobiol Dis       Date:  2009-11-24       Impact factor: 5.996

9.  Involvement of PGE2 and PGDH but not COX-2 in thrombin-induced cortical neuron apoptosis.

Authors:  Lakshmi Thirumangalakudi; Haripriya Vittal Rao; Paula Grammas
Journal:  Neurosci Lett       Date:  2009-01-21       Impact factor: 3.046

10.  Soluble aggregates of the amyloid-beta protein selectively stimulate permeability in human brain microvascular endothelial monolayers.

Authors:  Francisco J Gonzalez-Velasquez; Joseph A Kotarek; Melissa A Moss
Journal:  J Neurochem       Date:  2008-09-16       Impact factor: 5.372
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