Literature DB >> 1491357

Extending the phenotype of schizophrenia: implications for linkage analysis.

S Matthysse1, J Parnas.   

Abstract

On the basis of simulation studies, we suggest that most existing designs for studying linkage in schizophrenia do not have sufficient power to detect a major contributing locus, even if one is present. For this reason, recent failures to replicate reports of linkage in schizophrenia are not surprising. Inclusion in the linkage design of phenotypes genetically related to schizophrenia, but more commonly found in the relatives of schizophrenics than schizophrenia itself, may increase the power of linkage analysis substantially.

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Year:  1992        PMID： 1491357     DOI： 10.1016/0022-3956(92)90039-q

Source DB:  PubMed          Journal:  J Psychiatr Res        ISSN： 0022-3956            Impact factor:   4.791


  9 in total

1.  Does performance on the standard antisaccade task meet the co-familiality criterion for an endophenotype?

Authors:  Deborah L Levy; Elizabeth A Bowman; Larry Abel; Olga Krastoshevsky; Verena Krause; Nancy R Mendell
Journal:  Brain Cogn       Date:  2008-10-07       Impact factor: 2.310

Review 2.  Eye tracking dysfunction in schizophrenia: characterization and pathophysiology.

Authors:  Deborah L Levy; Anne B Sereno; Diane C Gooding; Gilllian A O'Driscoll
Journal:  Curr Top Behav Neurosci       Date:  2010

3.  Thought Disorder in Schizophrenia and Bipolar Disorder Probands, Their Relatives, and Nonpsychiatric Controls.

Authors:  Charity J Morgan; Michael J Coleman; Ayse Ulgen; Lenore Boling; Jonathan O Cole; Frederick V Johnson; Jan Lerbinger; J Alexander Bodkin; Philip S Holzman; Deborah L Levy
Journal:  Schizophr Bull       Date:  2017-05-01       Impact factor: 9.306

4.  Quantitative Measures of Craniofacial Dysmorphology in a Family Study of Schizophrenia and Bipolar Illness.

Authors:  Curtis K Deutsch; Deborah L Levy; Selya F R Price; J Alexander Bodkin; Lenore Boling; Michael J Coleman; Fred Johnson; Jan Lerbinger; Steven Matthysse; Philip S Holzman
Journal:  Schizophr Bull       Date:  2015-03-20       Impact factor: 9.306

5.  The power of linkage analysis of a disease-related endophenotype using asymmetrically ascertained sib pairs.

Authors:  Heejong Sung; Fei Ji; Deborah L Levy; Steven Matthysse; Nancy Role Mendell
Journal:  Comput Stat Data Anal       Date:  2009-03-15       Impact factor: 1.681

6.  Tailoring the definition of the clinical schizophrenia phenotype in linkage studies.

Authors:  Verena Krause; Olga Krastoshevsky; Michael J Coleman; J Alexander Bodkin; Jan Lerbinger; Lenore Boling; Fred Johnson; Anne Gibbs; Jonathan O Cole; Zhuying Huang; Nancy R Mendell; Deborah L Levy
Journal:  Schizophr Res       Date:  2009-11-26       Impact factor: 4.939

7.  The Genetic Basis of Thought Disorder and Language and Communication Disturbances in Schizophrenia.

Authors:  Deborah L Levy; Michael J Coleman; Heejong Sung; Fei Ji; Steven Matthysse; Nancy R Mendell; Debra Titone
Journal:  J Neurolinguistics       Date:  2010-05-01       Impact factor: 1.710

Review 8.  Disordered self in the schizophrenia spectrum: a clinical and research perspective.

Authors:  Josef Parnas; Mads Gram Henriksen
Journal:  Harv Rev Psychiatry       Date:  2014 Sep-Oct       Impact factor: 3.732

9.  Variability in clinical diagnoses during the ICD-8 and ICD-10 era.

Authors:  Julie Nordgaard; Kasper Jessen; Ditte Sæbye; Josef Parnas
Journal:  Soc Psychiatry Psychiatr Epidemiol       Date:  2016-07-14       Impact factor: 4.328
  9 in total

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