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Literature DB >> 1490876

Pneumocandins from Zalerion arboricola. I. Discovery and isolation.

R E Schwartz¹, D F Sesin, H Joshua, K E Wilson, A J Kempf, K A Goklen, D Kuehner, P Gailliot, C Gleason, R White.

Abstract

HPLC bioautography of the directed biosynthesis of Zalerion arboricola led to the discovery of pneumocandin B0 (L-688,786), a new antifungal and anti-Pneumocystis carinii lipopeptide. Isolation techniques were developed to separate this component from pneumocandin A0 (L-671,329) in fermentations of a mutant of Zalerion arboricola. A number of related compounds were also isolated, which differ from pneumocandins A0 and B0 in the hydroxylation patterns on the ornithine, homotyrosine, and proline.

Entities: Chemical Species

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Year: 1992 PMID： 1490876 DOI： 10.7164/antibiotics.45.1853

Source DB: PubMed Journal: J Antibiot (Tokyo) ISSN： 0021-8820 Impact factor: 2.649

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Cited

21 in total

1. Preliminary animal pharmacokinetics of the parenteral antifungal agent MK-0991 (L-743,872).

Authors: R Hajdu; R Thompson; J G Sundelof; B A Pelak; F A Bouffard; J F Dropinski; H Kropp
Journal: Antimicrob Agents Chemother Date: 1997-11 Impact factor: 5.191

2. Identification and characterization of the echinocandin B biosynthetic gene cluster from Emericella rugulosa NRRL 11440.

Authors: Ralph A Cacho; Wei Jiang; Yit-Heng Chooi; Christopher T Walsh; Yi Tang
Journal: J Am Chem Soc Date: 2012-10-01 Impact factor: 15.419

3. Engineering of Glarea lozoyensis for exclusive production of the pneumocandin B0 precursor of the antifungal drug caspofungin acetate.

Authors: Li Chen; Qun Yue; Yan Li; Xuemei Niu; Meichun Xiang; Wenzhao Wang; Gerald F Bills; Xingzhong Liu; Zhiqiang An
Journal: Appl Environ Microbiol Date: 2014-12-19 Impact factor: 4.792

Review 4. Natural products: a continuing source of novel drug leads.

Authors: Gordon M Cragg; David J Newman
Journal: Biochim Biophys Acta Date: 2013-02-18

5. Increased antifungal activity of L-733,560, a water-soluble, semisynthetic pneumocandin, is due to enhanced inhibition of cell wall synthesis.

Authors: M B Kurtz; C Douglas; J Marrinan; K Nollstadt; J Onishi; S Dreikorn; J Milligan; S Mandala; J Thompson; J M Balkovec
Journal: Antimicrob Agents Chemother Date: 1994-12 Impact factor: 5.191

10. Improvement in the titer of echinocandin-type antibiotics: a magnesium-limited medium supporting the biphasic production of pneumocandins A0 and B0.

Authors: J S Tkacz; R A Giacobbe; R L Monaghan
Journal: J Ind Microbiol Date: 1993-02

Pneumocandins from Zalerion arboricola. I. Discovery and isolation.

1. Preliminary animal pharmacokinetics of the parenteral antifungal agent MK-0991 (L-743,872).

2. Identification and characterization of the echinocandin B biosynthetic gene cluster from Emericella rugulosa NRRL 11440.

3. Engineering of Glarea lozoyensis for exclusive production of the pneumocandin B0 precursor of the antifungal drug caspofungin acetate.

Review 4. Natural products: a continuing source of novel drug leads.

5. Increased antifungal activity of L-733,560, a water-soluble, semisynthetic pneumocandin, is due to enhanced inhibition of cell wall synthesis.

6. A Saccharomyces cerevisiae mutant with echinocandin-resistant 1,3-beta-D-glucan synthase.

7. Use of cilofungin as direct fluorescent probe for monitoring antifungal drug-membrane interaction.

8. New semisynthetic pneumocandins with improved efficacies against Pneumocystis carinii in the rat.

9. Heterologous transformation of Zalerion arboricola.

10. Improvement in the titer of echinocandin-type antibiotics: a magnesium-limited medium supporting the biphasic production of pneumocandins A0 and B0.