Literature DB >> 1489205

Duration of the protective effect of polyaspartic acid on experimental gentamicin nephrotoxicity.

S K Swan1, D N Gilbert, S J Kohlhepp, J E Leggett, P W Kohnen, W M Bennett.   

Abstract

It is known that daily polyaspartic acid (PAA) protects the kidney from gentamicin nephrotoxicity in a standardized rat model despite marked cortical accumulation of the aminoglycoside. The present experiments address the duration of PAA protection. When administered every other day, PAA provided functional and histologic protection against gentamicin-induced toxicity. A stepwise reduction in nephroprotection occurred as the dosage interval was prolonged.

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Year:  1992        PMID： 1489205      PMCID： PMC284375          DOI： 10.1128/AAC.36.11.2556

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  11 in total

1.  Effect of dextran sulfate on renal accumulation of gentamicin.

Authors:  S Kikuchi; Y Aramaki; H Nonaka; S Tsuchiya
Journal:  Pharm Res       Date:  1990-06       Impact factor: 4.200

2.  Studies on the nephrotoxicity of aminoglycoside antibiotics and protection from these effects (9): Protective effect of inositol hexasulfate against tobramycin-induced nephrotoxicity.

Authors:  R Kojima; M Ito; Y Suzuki
Journal:  Jpn J Pharmacol       Date:  1990-07

3.  Attenuation of experimental tobramycin nephrotoxicity by ticarcillin.

Authors:  J English; D N Gilbert; S Kohlhepp; P W Kohnen; G Mayor; D C Houghton; W M Bennett
Journal:  Antimicrob Agents Chemother       Date:  1985-06       Impact factor: 5.191

4.  Protection against gentamicin-induced early renal alterations (phospholipidosis and increased DNA synthesis) by coadministration of poly-L-aspartic acid.

Authors:  D Beauchamp; G Laurent; P Maldague; S Abid; B K Kishore; P M Tulkens
Journal:  J Pharmacol Exp Ther       Date:  1990-11       Impact factor: 4.030

5.  Inhibition of renal membrane binding and nephrotoxicity of gentamicin by polyasparagine and polyaspartic acid in the rat.

Authors:  P D Williams; G H Hottendorf
Journal:  Res Commun Chem Pathol Pharmacol       Date:  1985-02

6.  Inhibition of gentamicin-induced nephrotoxicity by pyridoxal-5'-phosphate in the rat.

Authors:  S Kacew
Journal:  J Pharmacol Exp Ther       Date:  1989-01       Impact factor: 4.030

7.  Studies on the nephrotoxicity of aminoglycoside antibiotics and protection from these effects (3). Protective effect of latamoxef against tobramycin nephrotoxicity and its protective mechanism.

Authors:  R Kojima; M Ito; Y Suzuki
Journal:  Jpn J Pharmacol       Date:  1986-11

8.  Polyaspartic acid protects against gentamicin nephrotoxicity in the rat.

Authors:  L S Ramsammy; C Josepovitz; B P Lane; G J Kaloyanides
Journal:  J Pharmacol Exp Ther       Date:  1989-07       Impact factor: 4.030

9.  Long-term protection of polyaspartic acid in experimental gentamicin nephrotoxicity.

Authors:  S K Swan; S J Kohlhepp; P W Kohnen; D N Gilbert; W M Bennett
Journal:  Antimicrob Agents Chemother       Date:  1991-12       Impact factor: 5.191

10.  Polyaspartic acid prevents experimental aminoglycoside nephrotoxicity.

Authors:  D N Gilbert; C A Wood; S J Kohlhepp; P W Kohnen; D C Houghton; H C Finkbeiner; J Lindsley; W M Bennett
Journal:  J Infect Dis       Date:  1989-05       Impact factor: 5.226
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  1 in total

1.  Attenuation by daptomycin of gentamicin-induced experimental nephrotoxicity.

Authors:  N Thibault; L Grenier; M Simard; M G Bergeron; D Beauchamp
Journal:  Antimicrob Agents Chemother       Date:  1994-05       Impact factor: 5.191
  1 in total

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