Literature DB >> 1488556

Isolation and characterization of isoniazid-resistant mutants of Mycobacterium smegmatis and M. aurum.

B Heym1, S T Cole.   

Abstract

INH-resistant mutants of Mycobacterium aurum and M. smegmatis were isolated and characterized in an attempt to provide fresh insight into the activity of isoniazid (INH), a key antibiotic in the treatment of tuberculosis. In both cases, high levels of resistance were accompanied by slower growth rate, by loss of peroxidase and reduced catalase activities, although mycolic acid production was unaffected. A gene homologous to the katG gene of M. tuberculosis, encoding peroxidase-catalase, was detected in wild-type and INH-resistant strains and it appears that INH resistance may stem from the loss of its product.

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Year:  1992        PMID： 1488556     DOI： 10.1016/0923-2508(92)90067-x

Source DB:  PubMed          Journal:  Res Microbiol        ISSN： 0923-2508            Impact factor:   3.992


  15 in total

Review 1.  Multi drug resistant tuberculosis.

Authors:  K Chopra
Journal:  Indian J Pediatr       Date:  1996 Mar-Apr       Impact factor: 1.967

2.  Use of site-directed mutagenesis to probe the structure, function and isoniazid activation of the catalase/peroxidase, KatG, from Mycobacterium tuberculosis.

Authors:  B Saint-Joanis; H Souchon; M Wilming; K Johnsson; P M Alzari; S T Cole
Journal:  Biochem J       Date:  1999-03-15       Impact factor: 3.857

3.  Oxidative stress response and its role in sensitivity to isoniazid in mycobacteria: characterization and inducibility of ahpC by peroxides in Mycobacterium smegmatis and lack of expression in M. aurum and M. tuberculosis.

Authors:  S Dhandayuthapani; Y Zhang; M H Mudd; V Deretic
Journal:  J Bacteriol       Date:  1996-06       Impact factor: 3.490

4.  Iron homeostasis affects antibiotic-mediated cell death in Pseudomonas species.

Authors:  Jinki Yeom; James A Imlay; Woojun Park
Journal:  J Biol Chem       Date:  2010-05-17       Impact factor: 5.157

Review 5.  Antimycobacterial susceptibility testing: present practices and future trends.

Authors:  C B Inderlied
Journal:  Eur J Clin Microbiol Infect Dis       Date:  1994-11       Impact factor: 3.267

6.  Role of superoxide in catalase-peroxidase-mediated isoniazid action against mycobacteria.

Authors:  J Y Wang; R M Burger; K Drlica
Journal:  Antimicrob Agents Chemother       Date:  1998-03       Impact factor: 5.191

7.  Characterization of the katG gene encoding a catalase-peroxidase required for the isoniazid susceptibility of Mycobacterium tuberculosis.

Authors:  B Heym; Y Zhang; S Poulet; D Young; S T Cole
Journal:  J Bacteriol       Date:  1993-07       Impact factor: 3.490

8.  Tetracycline resistance determinants in Mycobacterium and Streptomyces species.

Authors:  Y Pang; B A Brown; V A Steingrube; R J Wallace; M C Roberts
Journal:  Antimicrob Agents Chemother       Date:  1994-06       Impact factor: 5.191

9.  Characterization of the katG and inhA genes of isoniazid-resistant clinical isolates of Mycobacterium tuberculosis.

Authors:  D A Rouse; Z Li; G H Bai; S L Morris
Journal:  Antimicrob Agents Chemother       Date:  1995-11       Impact factor: 5.191

10.  Antimycobacterial activities of antisense oligodeoxynucleotide phosphorothioates in drug-resistant strains.

Authors:  E Rapaport; A Levina; V Metelev; P C Zamecnik
Journal:  Proc Natl Acad Sci U S A       Date:  1996-01-23       Impact factor: 11.205
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